Corneal pain is a defense system that signals injury or loss of ocular surface homeostasis. However, not rarely patients may report significant symptoms while presenting few or no signs of inflammation. This clinical entity, defined as neuropathic pain, has gained increasing interest in recent years, and efforts have been made to clarify the pathophysiology.
“Neuropathic pain occurs when corneal nociceptors become dysfunctional. They develop increasing hypersensitivity to physiological or noxious stimuli, including air drafts, temperature change and endogenous chemical changes or may
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