Aerie Pharmaceuticals has initiated a clinical trial of AR-13503, a sustained release implant, for treatment of neovascular age-related macular degeneration or diabetic macular edema, according to a press release.
The implant, which is made of bio-erodible polyesteramide polymer, is designed for once every 6-month dosing by intravitreal injection. The small molecule drug inhibits both Rho kinase and protein kinase C over a sustained period.
The first-in-human clinical trial will include two phases. The first, a multicenter, open label, dose escalation study, will evaluate the safety and
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