The first patient has been enrolled in a phase 2b trial of topical ocular reproxalap for dry eye disease, according to a press release from Aldeyra Therapeutics.
Two concentrations of topical reproxalap, 0.1% and 0.25%, will be evaluated against vehicle over a 12-week treatment period in 300 patients with moderate dry eye disease.
Reproxalap is generated from the company’s aldehyde trap platform, and it sequesters and facilitates the degradation of pro-inflammatory aldehyde mediators, the release said.
Trial results are expected to be announced in the second half of the year.
Author: Healio ophthalmology
The professional pleasures and succession perils of rural practice
“I think the extent to which I have any balance at all, any mental balance, is because of being a farm kid and being raised in those isolated rural areas.” – James Earl Jones
“Country things are the necessary root of our life — and that remains true even of a rootless and tragically urban civilization. To live permanently away from the country is a form of slow death.” – Esther Meynell
Of the 7,000 or so private, independent ophthalmology practices in America, a significant number are operated as solo (Read more...)
Surgical techniques vary for adult and pediatric Boston KPro
When conventional full-thickness penetrating keratoplasty or corneal transplantation has a high risk for graft failure, an artificial cornea may be the alternative choice in an attempt to visually rehabilitate the patient. An artificial cornea may be considered in patients with one or more failed penetrating keratoplasties. Other considerations include vision worse than 20/200 in the involved eye with contralateral compromised vision without end-stage glaucoma or retinal detachment. Based on the WHO’s 2010 global blindness data, it has been estimated that bilateral corneal blindness
SFT pupilloplasty has role in endothelial keratoplasty cases
Endothelial keratoplasty involves the supplantation of the endothelial cell layer along with Descemet’s membrane, which may or may not be supported with the layer of stroma in the donor graft.
An important consideration during an endothelial keratoplasty procedure is preventing and minimizing the loss of endothelial cells during the process of donor tissue preparation and also while inserting and repositioning the graft in the anterior chamber. Pupilloplasty is often performed to prevent the escape of air into the vitreous cavity, maintain the effective air tamponade in the anterior
Ophthalmologists serve important purpose after natural disasters
Through care or supplies, volunteering ophthalmologists can fill a crucial need for communities, residents and patients affected by natural disasters.
Ophthalmologists can provide important medical support to patients in the wake of a natural disaster and should consider volunteering their services either at home or abroad, Richard K. Lee, MD, PhD, of Bascom Palmer Eye Institute, said.
“People often think, ‘Well, I’m an ophthalmologist, and here’s a situation where I can’t help.’ Everyone can help. In any disaster, as physicians, we really have an opportunity
Modern-day cataract surgery: Bad and boujee
For those premium cataract surgeons with a musical know-how, “Bad and Boujee” is a recent well-known hip-hop song by Migos and Lil Uzi Vert, known for the concept of “bad” meaning good-looking and “boujee” meaning stuck up, where pretty ladies were seen in regular environments such as wearing silk shirts on dirt bikes. So how does this concept translate to the modern-day cataract surgeon?
Bad and boujee can be related to the type of cataract being removed, from an early dysfunctional lens (boujee) to a mature cataract (bad) LOCS III (Read more...)
Local and global volunteer opportunities abound
I made my first mission ophthalmology trip in 1979 under the direction of my then-senior partner, William S. Harris, MD, of Dallas. We traveled to San Pedro Sula, Honduras, and spent 1 week performing phacoemulsification and planned extracapsular catar…
Is the value in volunteering professional or personal?
Click here to view the Cover Story to this Point/Counter.Volunteerism is a personal choice, but it does have professional implications. It is one of those things where it is always good that your patients feel that you are doing something in a humanita…
Forensic analysis, case review help define causes of IOL explantation
A study based on an extensive review of cases and forensic analysis of explanted IOLs provided reliable scientific data for the classification of causes that lead to explantation.
“IOL explantation is an infrequent but serious event that deserves attention. Knowing the causes of explantation is epidemiologically important because they might reflect inadequate surgical practices, inadequate materials or design. From knowing the causes, we get important insights on how to improve manufacturing, selection and implantation techniques,” Jorge L. Alió, MD, PhD, said.
About 8 years
Elderly man presents with acute-onset nonprogressive blurred vision in right eye
A 79-year-old man presented to Tufts New England Eye Center with a 6-week history of acute-onset nonprogressive blurred vision and reduced color vision in the right eye. The patient’s complete ocular and systemic review of systems was otherwise negative, including headache, weight loss, fevers or night sweats.
The patient’s medical history was notable for a remote history of prostate cancer that had been treated with radioactive seed implant in 1998. He had been recently hospitalized for renal failure of unclear etiology. His other medical conditions included insulin-dependent
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Adverum, Editas extend research collaboration
Adverum Biotechnologies and Editas Medicine have extended their collaboration agreement to explore the delivery of genome editing medicines to treat inherited retinal diseases, Adverum announced in a press release.
The companies are extending the research period through the third quarter of 2018, and Editas has a series of options exercisable between now and August 2020, the release said.
The collaboration focuses on utilizing Adverum’s adeno-associated viral vectors to deliver Editas’ CRISPR-based genome editing technologies in order to develop therapies for eye diseases, according
What qualifies as a stock market ‘plunge’?
I recently heard a financial reporter refer to a 100-point drop in the Dow Jones Industrial Average as “a 100-point plunge,” which made me laugh.
But then I thought, “What if the average investors were thinking the same thing, especially those older clients who were invested in the markets when 100 points was indeed a ‘plummet’ or plunge?” So, I decided to make some 2018 sense out of effect of market point movement to better put those into perspective.
To do that, and as a reference comparison, I think we (Read more...)
Mundipharma expands Santen partnership
Mundipharma has expanded a partnership with Santen Pharmaceutical, according to a press release.
The extension of an existing license for Saflutan (tafluprost) will add approximately 50 Middle Eastern and African markets.
In addition, the company will add Taptiqom (tafluprost/timolol) to its license in Canada, Australia, New Zealand, Latin America, the Middle East and Africa.
“We are delighted to further expand our ophthalmic portfolio as well as our successful partnership with Santen, ” Raman Singh, Mundipharma’s CEO, said in the release. “The extended licensing
Boston type 1 keratoprosthesis provides long-term visual acuity improvement
The Boston type 1 keratoprosthesis provided significant visual improvement in many eyes over the long term, according to a study.
The retrospective chart review of KPro implantations completed by a single surgeon at the Stein Eye Institute between May 1, 2004, and May 1, 2011, aimed to evaluate the long-term outcomes, complications and retention of the procedure. Patients’ preoperative ocular history, intraoperative data, and postoperative management and outcomes, including interval-corrected distance visual acuity (CDVA), were analyzed.
There were 74 KPros implanted in 58 eyes during
VIDEO: OSN/Wills Eye survey shows reputation matters
WAILEA, Hawaii — At Hawaiian Eye 2018, Carl D. Regillo, MD, discusses lessons learned from the recent survey sent to ophthalmologists in a joint effort by Ocular Surgery News and Wills Eye Hospital.
VIDEO: Patient selection key in EDOF and multifocal IOLs in post-LASIK patients
WAILEA, Hawaii — At Hawaiian Eye 2018, Eric D. Donnenfeld, MD, discusses pearls for cataract surgery using extended depth of focus and multifocal IOLs in patients who have had LASIK previously.
VIDEO: Lindstrom discusses Corboy Award, Hawaiian Eye Foundation
WAILEA, Hawaii — At Hawaiian Eye 2018, Richard L. Lindstrom, MD, discusses being awarded the Philip M. Corboy Award and the work of the Hawaiian Eye Foundation. To find out more about the Hawaiian Eye Foundation or to get involved, visit http://hawaiianeyefoundation.org/.
VIDEO: New EDOF lens shows advantages in early trials
WAILEA, Hawaii — At Hawaiian Eye 2018, John A. Hovanesian, MD, discusses early results implanting the SC9 extended depth of focus IOL (Cord) for presbyopia correction in cataract surgery.
Less surgically induced astigmatism seen with MICS
Patients with age-related cataracts who underwent microincision cataract surgery had less short-term and long-term surgically induced astigmatism compared with patients who underwent standard-incision cataract surgery.Researchers conducted a meta-analy…