Assessing the Cone Photoreceptor Mosaic in Eyes with Pseudodrusen and Soft Drusen In Vivo Using Adaptive Optics Imaging – Corrected Proof

Purpose: To investigate the cone photoreceptor mosaic in eyes with pseudodrusen as evidenced by the presence of subretinal drusenoid deposits (SDD) and conventional drusen using adaptive optics (AO) imaging integrated into a multimodal imaging approach.Design: Observational case series.Participants: Eleven patients (11 eyes) with pseudodrusen and 6 patients (11 eyes) with conventional drusen.Methods: Consecutive patients were examined using near-infrared reflectance (IR) confocal scanning laser ophthalmoscopy (SLO) and eye-tracked spectral-domain optical coherence tomography (SD-OCT) and flood-illuminated retinal AO camera of nonconfluent pseudodrusen or conventional drusen. Correlations were made between the IR-SLO, SD-OCT, and AO images. Cone density analysis was performed on AO (Read more...)

In Vivo Confocal Microscopy Analyses of Corneal Microstructural Changes in a Prospective Study of Collagen Cross-linking in Keratoconus – Corrected Proof

Purpose: To use in vivo confocal microscopy (IVCM) to quantitatively analyze microstructural changes over time, after corneal collagen cross-linking for keratoconus.Design: Prospective cohort study.Participants: A total of 38 eyes of 38 patients undergoing collagen cross-linking for keratoconus.Methods: Prospective, clinical cohort study of corneal collagen cross-linking in progressive keratoconus. Laser scanning IVCM performed preoperatively and at 1, 3, 6, and 12 months postoperatively.Main Outcome Measures: Density of corneal sub-basal nerves, anterior and posterior keratocytes, and corneal endothelium.Results: Compared with baseline values, the mean sub-basal nerve density decreased significantly at 1, 3, and 6 months postoperatively (P < 0.01); however, this returned to preoperative values (Read more...)

Advances in Anterior Segment OCT

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Dr. Roger Steinert explores some of the latest advancements in anterior segment optical coherence tomography (OCT) and their potential beneficial impact on clini…

VMA does not affect anti-VEGF treatment for polypoidal choroidal vasculopathy

The presence of vitreomacular adhesion had an insignificant effect on visual outcomes after intravitreal anti-VEGF injections for the treatment of polypoidal choroidal vasculopathy, according to a study.The retrospective study included 104 eyes of 102 patients with polypoidal choroidal vasculopathy. Eyes were assigned to two groups; 23 eyes had vitreomacular adhesion (VMA) and 81 eyes did not have VMA.Investigators compared logMAR best corrected visual acuity and central macular thickness between the groups at baseline and at 1, 3, 6 and 12 months after anti-VEGF treatment.

NICE recommends reimbursement for Jetrea in England, Wales

The final ruling recommended reimbursing Jetrea (ocriplasmin, ThromboGenics/Alcon) for patients with vitreomacular traction and full-thickness macular holes up to 400 µm in diameter in the absence of epiretinal membrane.The ruling also recommended reimbursing Jetrea when used to treat patients with metamorphopsia, an early symptom of vitreomacular traction.