Objective: Xeroderma pigmentosum (XP) is a rare autosomal recessive disease caused by mutations in DNA repair genes. Clinical manifestations of XP include mild to extreme sensitivity to ultraviolet radiation resulting in inflammation and neoplasia in s…
Proximal Tarsal Attachments of the Levator Aponeurosis: Implications for Blepharoptosis Repair – Corrected Proof
Purpose: To examine the tarsal attachments of the levator aponeurosis.Design: Experimental anatomic study.Participants: Sixteen orbits from 12 fresh frozen white cadavers.Methods: Eight specimens served as controls. In the remaining 8 specimens from 4 …
Actinic Granuloma of the Conjunctiva in Young Women – Corrected Proof
Objective: To report the occurrence of actinic granuloma of the conjunctiva in young women.Design: Retrospective case series.Participants: Three eyes of 3 young women with a unilateral conjunctival mass of recent onset.Methods: Three young women (21, 2…
Strategy for the Management of Complex Retinal Detachments: The European Vitreo-Retinal Society Retinal Detachment Study Report 2 – Corrected Proof
Objective: To study the outcome of the treatment of complex rhegmatogenous retinal detachments (RRDs).Design: Nonrandomized, multicenter, retrospective study.Participants: One hundred seventy-six surgeons from 48 countries spanning 5 continents reporte…
Strategy for the Management of Uncomplicated Retinal Detachments: The European Vitreo-Retinal Society Retinal Detachment Study Report 1 – Corrected Proof
Objective: To study success and failure in the treatment of uncomplicated rhegmatogenous retinal detachments (RRDs).Design: Nonrandomized, multicenter retrospective study.Participants: One hundred seventy-six surgeons from 48 countries spanning 5 conti…
Analysis of a Novel Protocol of Pulsed Intravenous Cyclophosphamide for Recalcitrant or Severe Ocular Inflammatory Disease – Corrected Proof
Purpose: To analyze the success rate of pulsed intravenous (IV) cyclophosphamide (CyP) for noninfectious ocular inflammatory disease and to identify risk factors for failure of therapy.Design: Retrospective, interventional, noncomparative cohort study.Participants: One hundred ten eyes of 65 patients.Methods: Through a computer search of the Massachusetts Eye Research and Surgery Institution’s database, we identified patients who were treated with IV CyP between May 2005 and April 2012. We obtained demographic and clinical information through review of the electronic health record of each patient.Main Outcomes Measures: Clinical response, corticosteroid-sparing effect, recurrence rate, calculated “risk factors” for failure, visual acuity, and adverse reactions.Results: (Read more...)