Author: The Medical News

Eye abnormalities may help reveal features of early-stage Alzheimer’s disease, says study

​Investigators at the Cedars-Sinai Regenerative Medicine Institute have discovered eye abnormalities that may help reveal features of early-stage Alzheimer’s disease. Using a novel laboratory rat model of Alzheimer’s disease and high-resolution imaging techniques, researchers correlated variations of the eye structure, to identify initial indicators of the disease.

Researchers develop new software to aid cardiovascular risk diagnosis based on fundus image processing

Researchers from the Universitat Politècnica de València, the Hospital General de Valencia and the Ophthalmology Unit of the Foundation for the Health and Biomedical Research of the Comunitat Valenciana (FISABIO-Oftalmología Médica) have developed a new software to aid cardiovascular risk diagnosis based on fundus image processing.

Aerpio Therapeutics doses first patient in AKB-9778 Phase 2 trial for diabetic macular edema treatment

Aerpio Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on advancing innovative therapies for vascular diseases, today announced that it has dosed the first patient in a Phase 2 trial evaluating AKB-9778, a Tie2 activator, alone and in combination with ranibizumab (Lucentis) for the treatment of diabetic macular edema (DME). AKB-9778 is a first-in-class inhibitor of human protein tyrosine phosphatase beta (HPTPβ) that activates the Tie2 pathway to promote vascular stability, preventing abnormal blood vessel growth and vascular leak.