Tag: Nanomedicine

Algae-Based Microrobots Deliver Antibiotics within Lungs

Researchers at the University of California San Diego have developed a microrobot system to treat bacterial pneumonia. The microrobots consist of living algal cells that can swim very effectively in biological fluids, allowing them to navigate throughout the lungs and deliver drugs to difficult-to-reach areas. The algal cells are studded with antib (Read more...)

DNA-Based Nanorobot Interacts with Live Cells

Researchers at INSERM (Institut national de la santé et de la recherche médicale) in France, and collaborators, have developed a DNA-based nanorobot called the Nano-winch. The tiny creation is made using DNA molecules and a “DNA Origami” approach. The tiny robot is so small that it can land on a cell surface and interact w (Read more...)

Optical Tweezers Turn Neutrophils into Microrobots

The possibility of using our own cells to perform medical tasks within the body is tantalizing, as it would avoid the immune responses that can occur with synthetic objects. Researchers at Jinan University in China have now developed a method to control and move white blood cells within a living organism. The technology relies on […]

Nanoparticle Vaccine for Many SARS-Like Coronaviruses

Researchers at the California Institute of Technology, better known as Caltech, have developed a nanoparticle vaccine that appears to confer broad protection against SARS-like betacoronaviruses. This includes SARS-CoV-2, responsible for the current pandemic, and SARS-CoV, which caused the original SARS pandemic in the early 2000s. The vaccine consi (Read more...)

Lipid Nanodiscs Unlock the Potential of Cytokine Treatment

Researchers at the University of Texas at Austin created a nanocarrier for stem cell factor, a regenerative cytokine. The nanotechnological approach renders the treatment much safer, as previous attempts to use stem cell factor as a pro-angiogenic treatment have been hampered by severe allergic reactions in some recipients. This latest technology h (Read more...)

Molecular Robots Swarm to Deliver Cargo

Researchers at Hokkaido University in Japan created molecular robots that can employ swarm behaviors to move and release small cargoes. The robots can be controlled using light, and they consist of biological components, including DNA, microtubules, which are a cytoskeletal component, and kinesin, which is a motor protein that interacts with microt (Read more...)

Excitable Nanoparticles Destroy Endometriosis Lesions

Researchers at Oregon State University developed a nanoparticle system that can aid with the removal of endometrial lesions in a minimally invasive fashion. In endometriosis, endometrial tissue grows outside of the uterus, causing pain and affecting fertility. Surgery to remove these lesions is often unsuccessful and repeat surgeries are often requ (Read more...)

Highly Efficient Liposome-Based Drug Screening

Researchers at the University of Copenhagen have developed a technique that lets them screen the interactions of drug candidates with target molecules extremely rapidly, inexpensively, and with very small amounts of starting materials and reagents. The highly efficient method , which the researchers have called “single particle combinatorial (Read more...)

Modified Red Blood Cells for COVID-19 Vaccination

Researchers at McMaster University in Ontario, Canada created engineered red blood cells to act as a new COVID-19 vaccine technology. The cell membranes have been studded with the SARS-CoV-2 spike protein, and in experiments the researchers have conducted in mice the cells can trigger an immune response with minimal side-effects. The team reports t (Read more...)

Capsule Delivers and Injects mRNA into Stomach

Researchers at MIT have created an oral mRNA delivery system that could provide an alternative to injectable mRNA vaccines. It could also enable RNA or DNA therapies that are intended to treat gastrointestinal diseases. mRNA has shown its therapeutic potential in spectacular fashion, providing the powerhouse behind some of the world’s most su (Read more...)

Anti-COVID Nanobubbles Act as Viral Decoys

Researchers at Northwestern University have discovered naturally-occurring extracellular vesicles in the blood that contain the ACE2 protein, which is the cellular target of SARS-CoV-2. The vesicles act as a binding site for viral particles within the body, and prevent them from binding to and infecting cells. Unlike vaccines, therapeutics based on (Read more...)

Protein Coating Protects Nanoparticles from Immune Attack

Researchers at the University of Pennsylvania School of Medicine have created a new coating for nanoparticles that can help to protect them from attacks by the immune system. The approach, which uses naturally occurring proteins that can inhibit the complement system, can significantly reduce immune destruction of nanoparticles, meaning that more m (Read more...)

Hairy Nanocrystals Capture Chemo Drugs

Researchers at Penn State working with collaborators have developed a nanomaterial that can ‘mop up’ chemotherapeutics in the bloodstream, helping to reduce off-target effects. The technology is intended for use in situations where a chemotherapeutic can be delivered precisely to the site of a tumor, and not in situations where it is de (Read more...)

Nanotransfection Device for Tissue Reprogramming In Situ

Genetic modification offers huge potential in treating a wide variety of conditions, but the devil is in the details. Previously explored methods to deliver genes into cells, such as using viral vectors, have been connected with safety issues. As such, the potential of gene therapy has not yet been fully realized. Technological advances may offer [ (Read more...)

Flu Virus-Inspired Nanoparticles for mRNA Delivery

Researchers at the University of California San Diego developed a new delivery technique for mRNA. The method involves flu virus-inspired nanoparticles that can escape endosomes, the acidic vesicles that engulf and destroy materials that attempt to enter cells. The nanoparticles contain a protein receptor that allows them to unlock the endosomes an (Read more...)