Tag: Nanomedicine

Nanoparticles Get Lymphatic Vessels Pumping

Researchers at the Georgia Institute of Technology have developed a nanotechnological solution for lymphedema, a failure of the lymphatic system that results in uncomfortable and irreversible fluid retention. Previous research efforts have focused on trying to grow new lymphatic vessels, but these researchers have taken a different approach, and in (Read more...)

Bottlebrush Particle for Synergistic Drug Combinations

A scientific team at MIT has developed a bottlebrush-shaped nanoparticle that can deliver combinations of drugs for synergistic efficacy. The particles contain a central backbone and demonstrate side-chains that sprout from this backbone, similar to the handle and bristles of a bottlebrush. Several drugs can be mixed in different ratios and combine (Read more...)

Extra Hot Nanoparticles for Cancer Therapy

Researchers at Oregon State University created a new type of hyperthermic magnetic nanoparticle that is intended to assist in destroying tumors through localized heating under an alternating magnetic field. Previous iterations of such technologies could heat up to about 44 degrees Celsius (111 F), which was only effective in easy-to-access tumors t (Read more...)

Making Tumors Tastier for the Immune System

Researchers at The University of Texas MD Anderson Cancer Center have developed a nanotechnology platform that can make cancer cells more vulnerable to immune attack in the body. The researchers call their system the bispecific tumor-transforming nanoconjugate (BiTN) platform. The idea is to make solid tumors more appealing for the immune system by (Read more...)

Improved Membrane Coating for Anti-Cancer Nanoparticles

Scientists at the University of Eastern Finland have developed a technique that lets them improve the coating of nanoparticles when using cell membranes. Cell membranes offer a lot of benefits as a coating for synthetic nanoparticles, including shielding from the immune system, prolonged circulation times and improved tumor accumulation. However, c (Read more...)

Magnetic Bacteria Target Tumors

Scientists at ETH Zurich in Switzerland have unveiled a technique that weaponizes bacterial cells against tumors. The approach involves using bacteria called Magnetospirillum that are naturally magnetic by virtue of the iron oxide particles they contain. The researchers use a rotating magnetic field applied at the tumor location from outside the bo (Read more...)

DNA Nets Capture Sars-CoV-2 for Detection and Inhibition

A team at the University of Illinois at Urbana-Champaign has developed a DNA net system that can ensnare Sars-CoV-2 and bind to the notorious spike protein. The nets contain aptamers that bind the spike protein and emit an intense fluorescent signal once they’re bound together to the protein. This signal can be easily measured using [… (Read more...)

Algae-Based Microrobots Deliver Antibiotics within Lungs

Researchers at the University of California San Diego have developed a microrobot system to treat bacterial pneumonia. The microrobots consist of living algal cells that can swim very effectively in biological fluids, allowing them to navigate throughout the lungs and deliver drugs to difficult-to-reach areas. The algal cells are studded with antib (Read more...)

DNA-Based Nanorobot Interacts with Live Cells

Researchers at INSERM (Institut national de la santé et de la recherche médicale) in France, and collaborators, have developed a DNA-based nanorobot called the Nano-winch. The tiny creation is made using DNA molecules and a “DNA Origami” approach. The tiny robot is so small that it can land on a cell surface and interact w (Read more...)

Optical Tweezers Turn Neutrophils into Microrobots

The possibility of using our own cells to perform medical tasks within the body is tantalizing, as it would avoid the immune responses that can occur with synthetic objects. Researchers at Jinan University in China have now developed a method to control and move white blood cells within a living organism. The technology relies on […]

Nanoparticle Vaccine for Many SARS-Like Coronaviruses

Researchers at the California Institute of Technology, better known as Caltech, have developed a nanoparticle vaccine that appears to confer broad protection against SARS-like betacoronaviruses. This includes SARS-CoV-2, responsible for the current pandemic, and SARS-CoV, which caused the original SARS pandemic in the early 2000s. The vaccine consi (Read more...)

Lipid Nanodiscs Unlock the Potential of Cytokine Treatment

Researchers at the University of Texas at Austin created a nanocarrier for stem cell factor, a regenerative cytokine. The nanotechnological approach renders the treatment much safer, as previous attempts to use stem cell factor as a pro-angiogenic treatment have been hampered by severe allergic reactions in some recipients. This latest technology h (Read more...)

Molecular Robots Swarm to Deliver Cargo

Researchers at Hokkaido University in Japan created molecular robots that can employ swarm behaviors to move and release small cargoes. The robots can be controlled using light, and they consist of biological components, including DNA, microtubules, which are a cytoskeletal component, and kinesin, which is a motor protein that interacts with microt (Read more...)

Excitable Nanoparticles Destroy Endometriosis Lesions

Researchers at Oregon State University developed a nanoparticle system that can aid with the removal of endometrial lesions in a minimally invasive fashion. In endometriosis, endometrial tissue grows outside of the uterus, causing pain and affecting fertility. Surgery to remove these lesions is often unsuccessful and repeat surgeries are often requ (Read more...)

Highly Efficient Liposome-Based Drug Screening

Researchers at the University of Copenhagen have developed a technique that lets them screen the interactions of drug candidates with target molecules extremely rapidly, inexpensively, and with very small amounts of starting materials and reagents. The highly efficient method , which the researchers have called “single particle combinatorial (Read more...)

Modified Red Blood Cells for COVID-19 Vaccination

Researchers at McMaster University in Ontario, Canada created engineered red blood cells to act as a new COVID-19 vaccine technology. The cell membranes have been studded with the SARS-CoV-2 spike protein, and in experiments the researchers have conducted in mice the cells can trigger an immune response with minimal side-effects. The team reports t (Read more...)

Capsule Delivers and Injects mRNA into Stomach

Researchers at MIT have created an oral mRNA delivery system that could provide an alternative to injectable mRNA vaccines. It could also enable RNA or DNA therapies that are intended to treat gastrointestinal diseases. mRNA has shown its therapeutic potential in spectacular fashion, providing the powerhouse behind some of the world’s most su (Read more...)

Anti-COVID Nanobubbles Act as Viral Decoys

Researchers at Northwestern University have discovered naturally-occurring extracellular vesicles in the blood that contain the ACE2 protein, which is the cellular target of SARS-CoV-2. The vesicles act as a binding site for viral particles within the body, and prevent them from binding to and infecting cells. Unlike vaccines, therapeutics based on (Read more...)