Tag: Nanomedicine

DNA Circuits to Identify Cancer Cells

Researchers from Duke University have developed a new DNA-based tool to identify cancer cells. Their system is a DNA circuit. DNA binding to specific cell markers produces a signal if and only if two specific proteins are present, helping to improve specificity and reduce false positives in cancer cell detection. The researchers also hope that [&he (Read more...)

Self-Propelled Enzyme-Coated Liposomes for Drug Delivery

Researchers at Penn State have developed self-propelled liposomes that can migrate towards or away from chemical signals, paving the way for self-directed drug delivery vehicles that can actively target a specific area in the body. The technology may help to enhance efficacy and reduce side-effects of drugs in a variety of applications. Because of (Read more...)

Self-Propelled Enzyme-Coated Liposomes for Drug Delivery

Researchers at Penn State have developed self-propelled liposomes that can migrate towards or away from chemical signals, paving the way for self-directed drug delivery vehicles that can actively target a specific area in the body. The technology may help to enhance efficacy and reduce side-effects of drugs in a variety of applications. Because of (Read more...)

Nanoparticles Cross Blood-Brain Barrier to Treat Stroke

Ischemic strokes can cause havoc in the brain, but early and properly directed treatment can mitigate a lot of damage. While there are a number of options to unclog blocked arteries, the potential to provide additional drug therapy remains mostly unexplored because of the difficulty in getting medications past the blood-brain barrier. Now, research (Read more...)

Optical Nanoprobes Monitor Neural, Cardiac Cell Activity

Monitoring neurons and other excitable cells in vivo for research and clinical applications has usually required the use of electrode arrays. These are quite limited in their electrode density and the area that they can cover. Moreover, the amount of signal generated by the neurological system overwhelms any attempts at building large scale electro (Read more...)

Controllable Microswimmers Move Around Individual Cells in 3D

Manipulating individual cells and microscopic particles may be extremely valuable for testing new therapies, targeting tumors, and for studying the underlying causes of disease, but it is very difficult to directly manipulate individual cells within an environment shared with other cells. A collaboration of researchers from University of California (Read more...)

3D Liquid-Cell Electron Microscopy Imaging Now Possible

Electron microscopy revealed a world that exists at scales smaller than the wavelength of light. Advancements in this field have allowed scientists to visualize ever more objects and processes, but actually seeing living cells in 3D and within a liquid environment has been impossible. Now, a team of researchers from Penn State University, Virginia (Read more...)

Peptide Particles Ferry Drugs Across Blood-Brain Barrier

Most drugs, genetic materials, and other therapeutic agents are very difficult to use inside the brain because of the blood-brain barrier. There have been attempts to use ultrasound and microbubbles to create temporary passages through the barrier, including as a possible therapy for Alzheimer’s disease, but this is approach is not easy or id (Read more...)

Light Activated Compound Kills Hypoxic Tumors

Photodynamic therapy is a technique that relies on photosensitizer chemicals to generate reactive species that kill cancer cells. These compounds can be delivered into tumors and then light is used to activate them. One of the main reasons for the slow adoption of this technology is that tumors are usually oxygen deprived and the photosensitizers [ (Read more...)

Minimally Invasive Biopsies Provide Maximum Pathology Data

Current pathology techniques for analyzing biopsy tissues are lacking in their ability to detect cancer in small samples. Being able to rapidly study the distribution of protein expression within cells, gathered from minuscule samples, could be an important tool for early diagnosis and monitoring of cancer. Now, researchers at National University o (Read more...)

Bacterial Swarmbots to Produce Biologic Drugs

Biologics, being a group of drugs synthesized from biological sources, are often produced using bacteria. The manufacturing processes are usually slow and laborious, though they do benefit from economies of scale. Producing small quantities of biologics is typically limited to research labs, and even there it is limited in scope. Researchers at Duk (Read more...)