Tag: Genetics

Eyevensys Non-Viral Gene Therapy for Ocular Diseases: Interview with Patricia Zilliox, CEO of Eyevensys

Eyevensys, a clinical-stage biotechnology company based in France, has developed a method to perform non-viral gene therapy in the eye, with the aim of treating ocular diseases. The system uses ocular electrotransfection to deliver therapeutic genes into the eye. Consisting of an ocular device and an electrical pulse generator, the system can deliv (Read more...)

Artificial Protein Switch for Smart Cell Therapies

Researchers from University of California, San Francisco and the University of Washington have developed a new artificial protein switch, dubbed LOCKR. Their work demonstrates that the new switch can be used to control many intracellular processes, including mediating molecular traffic inside a cell, degrading specific proteins, and causing a cell (Read more...)

Using Microparticles to Measure Oxygen in Tissues

The field of tissue engineering is rapidly progressing, in large part thanks to hydrogel scaffolds that provide a comfortable home for new cells. A major issue that researchers bump against is tracking how well oxygen reaches freshly grown cells within such scaffolds, which can indicate how well the new cells are generally functioning. Now, researc (Read more...)

Generating Hallucinations Using Optogenetics

About a decade ago, Karl Deisseroth of Stanford University developed a technology called optogenetics. It allows scientists to stimulate individual nerve cells using light beams within the brains of live and moving animals. Now, this technology has been used to generate visual hallucinations within lab mice, causing them to act as though the things (Read more...)

New High-Res Holographic Microscope to Study Live Cells

Nanolive, a spinoff company of École polytechnique fédérale de Lausanne (EPFL) in Switzerland, has just introduced a holographic microscope that can image live cells at high resolution over extended time periods. Nanolive’s CX-A device relies on a low energy light beam to penetrate the sample, which does not interfere wit (Read more...)

Microfluidic Chip Allows Embryonic Stem Cells to Differentiate

Complex multicellular organisms, such as ourselves, start out from stem cells that differentiate into different kinds of cells. This process is controlled by groups of cells that secrete special signaling molecules called morphogens, which guide nearby stem cells to turn into the kinds of cells that should be located in that region. This is an [&he (Read more...)

Low Cost Medical Devices for Low-Resource Regions: Interview with Prof. Saad Bhamla, Georgia Tech

Advances in medical technology continue apace, with sophisticated new medical devices and therapies becoming available on an ongoing basis. However, medical technology often comes at a premium, and for low-resource regions sometimes even relatively basic medical devices, such as hearing aids, are inaccessible because they are too expensive. Similar (Read more...)

Scientists Develop Accurate Model of Blood-Brain Barrier

The blood-brain barrier (BBB) is the primary reason that so few medicines exist to treat brain conditions. Drugs that can attack tumors elsewhere usually can’t penetrate the defenses of the BBB, so figuring out how to get through it is important for the development of future drugs and other therapies. There have been attempts to […]

Liquid Biopsy for Monitoring Transplanted Stem Cells

Researchers from the University of Maryland, University of Pennsylvania, and Emory University have demonstrated that a blood test can be used to track the efficacy of transplanted stem cells. They analyzed tiny cellular components called exosomes that were secreted from transplanted stem cells. “Exosomes contain the signals of the cells they& (Read more...)

3D Printed ELISA Pipette Tips for Low Cost Medical Testing

Researchers at the University of Connecticut have developed a 3D printed enzyme-linked immunosorbent assay (ELISA) device, which fits onto a normal pipette and substantially reduces the time and cost of this common medical test. The device could allow for medical testing in remote or low-resource regions, where such tests would otherwise be unavail (Read more...)