Tag: Genetics

New Customizable Bio-Ink for Printing Organs, Tissues

3D printing of tissues and organs requires a bio-ink that can host the living cells that are required for every unique application. A viable construct requires an extracellular matrix that will have the right mechanical and biochemical properties for the intended cells. Researchers at Rutgers University believe they’re on track to being able (Read more...)

Genomic Profiling for Precision Medicine: Interview with David Spetzler, Caris Life Sciences

Caris Life Sciences, a Dallas-based innovator in molecular science focused on fulfilling the promise of precision medicine, has developed the MI Genomic Profiling Similarity (GPS) score to compare the molecular characteristics of specific tumors against those in the Caris database. This allows clinicians to identify the molecular subtype of their p (Read more...)

Device Links Up to 10 Organ Chips to Form Body-on-a-Chip

Researchers at the Harvard Wyss Institute have developed a “body-on-a-chip” consisting of up to 10 organ-on-a-chip devices that are linked together to mimic blood flow between different organ systems. The new system allows for more comprehensive drug testing, enabling researchers to see the effects of a drug on multiple organ systems si (Read more...)

Eyevensys Non-Viral Gene Therapy for Ocular Diseases: Interview with Patricia Zilliox, CEO of Eyevensys

Eyevensys, a clinical-stage biotechnology company based in France, has developed a method to perform non-viral gene therapy in the eye, with the aim of treating ocular diseases. The system uses ocular electrotransfection to deliver therapeutic genes into the eye. Consisting of an ocular device and an electrical pulse generator, the system can deliv (Read more...)

Artificial Protein Switch for Smart Cell Therapies

Researchers from University of California, San Francisco and the University of Washington have developed a new artificial protein switch, dubbed LOCKR. Their work demonstrates that the new switch can be used to control many intracellular processes, including mediating molecular traffic inside a cell, degrading specific proteins, and causing a cell (Read more...)

Using Microparticles to Measure Oxygen in Tissues

The field of tissue engineering is rapidly progressing, in large part thanks to hydrogel scaffolds that provide a comfortable home for new cells. A major issue that researchers bump against is tracking how well oxygen reaches freshly grown cells within such scaffolds, which can indicate how well the new cells are generally functioning. Now, researc (Read more...)

Generating Hallucinations Using Optogenetics

About a decade ago, Karl Deisseroth of Stanford University developed a technology called optogenetics. It allows scientists to stimulate individual nerve cells using light beams within the brains of live and moving animals. Now, this technology has been used to generate visual hallucinations within lab mice, causing them to act as though the things (Read more...)

New High-Res Holographic Microscope to Study Live Cells

Nanolive, a spinoff company of École polytechnique fédérale de Lausanne (EPFL) in Switzerland, has just introduced a holographic microscope that can image live cells at high resolution over extended time periods. Nanolive’s CX-A device relies on a low energy light beam to penetrate the sample, which does not interfere wit (Read more...)

Microfluidic Chip Allows Embryonic Stem Cells to Differentiate

Complex multicellular organisms, such as ourselves, start out from stem cells that differentiate into different kinds of cells. This process is controlled by groups of cells that secrete special signaling molecules called morphogens, which guide nearby stem cells to turn into the kinds of cells that should be located in that region. This is an [&he (Read more...)

Low Cost Medical Devices for Low-Resource Regions: Interview with Prof. Saad Bhamla, Georgia Tech

Advances in medical technology continue apace, with sophisticated new medical devices and therapies becoming available on an ongoing basis. However, medical technology often comes at a premium, and for low-resource regions sometimes even relatively basic medical devices, such as hearing aids, are inaccessible because they are too expensive. Similar (Read more...)