Tag: Genetics

Wearable Air Sampler to Assess SARS-CoV-2 Exposure

Researchers at Yale University created a wearable air sampler clip that can be worn on clothing and which can bind aerosols present in the environment. The clip can later be analyzed to determine the level of SARS-CoV-2 exposure while it was worn. The low-cost, battery-free technology could allow people to identify unsafe indoor environments that [ (Read more...)

Quantum Sensor to Detect SARS-CoV-2 More Accurately

Researchers at MIT have designed a quantum sensor to detect SARS-CoV-2. While the device is still theoretical, the researchers have used mathematical simulations to show its potential, and the data and design indicate that it may be faster, more accurate, and less expensive than the current gold-standard technique, PCR. The system is based on nanod (Read more...)

Light-Activated PCR Assay

Researchers at Ludwig-Maximilians-Universität München in Germany have developed a light-activated form of the enzymes that power the polymerase chain reaction (PCR) assay. The assay has gained recent fame among the general public because of its use as a COVID-19 diagnostic tool. The technique could lead to alternatives to current heat-act (Read more...)

Nanotransfection Device for Tissue Reprogramming In Situ

Genetic modification offers huge potential in treating a wide variety of conditions, but the devil is in the details. Previously explored methods to deliver genes into cells, such as using viral vectors, have been connected with safety issues. As such, the potential of gene therapy has not yet been fully realized. Technological advances may offer [ (Read more...)

Flu Virus-Inspired Nanoparticles for mRNA Delivery

Researchers at the University of California San Diego developed a new delivery technique for mRNA. The method involves flu virus-inspired nanoparticles that can escape endosomes, the acidic vesicles that engulf and destroy materials that attempt to enter cells. The nanoparticles contain a protein receptor that allows them to unlock the endosomes an (Read more...)

3D Blood Vessel Map Reveals Location of Stem Cells

Scientists at Johns Hopkins used a combination of molecular labeling and imaging techniques to create a three-dimensional map of the blood vessels in the mouse skull. Their approach also reveals niches where stem cell populations lurk, which could help researchers to understand how blood vessels and cells behave in various states of disease or inju (Read more...)

DNA Aptamers for Rapid COVID-19 Testing: Interview with Steven Goh, CEO of Achiko and Dr. Michael Edel, Inventor of AptameX

Achiko, a company based in Switzerland, has developed AptameX, a saliva-based rapid COVID-19 test. The technology is based on DNA aptamers that are bound to gold nanoparticles. On binding with a viral protein the gold nanoparticles are released, causing a measurable color change. The test takes approximately 15 minutes in total, with the user spend (Read more...)

Wireless Photoelectric Implant for Optogenetics Research

Scientists at Ecole Polytechnique Fédérale de Lausanne in Switzerland created a wireless photoelectric implant that allows them to activate or suppress certain neurons in the mouse spinal cord. The flexible implant is controlled through Bluetooth and contains miniaturized LEDs that emit red light, which helps to avoid absorption and r (Read more...)

DNA Sensor Rapidly Determines If a Virus is Infectious

Researchers at the University of Illinois Urbana-Champaign have developed a sensor that can rapidly detect a virus in a sample. It can also identify whether the viral particles are still infectious. So far, the researchers have trialed the technology to detect human adenovirus and SARS-CoV-2. It can provide an answer between 30 minutes and two [&he (Read more...)

Eyevensys Electrotransfection System for Ocular Disease: Interview with Patricia Zilliox, CEO

Eyevensys, a medtech company based in France, has developed the Eyevensys Electrotransfection System, a non-viral transfection system for the treatment of ocular diseases. So far, the firm has demonstrated the safety of the technique in treating noninfectious uveitis and is developing treatments for geographic atrophy, retinitis pigmentosa, and wet (Read more...)

Wireless Light Implant for Optogenetics Without Skull Damage

Researchers at the University of Arizona have overcome a major limitation of optogenetics with their wireless and battery-free implant that can shine light through the skull. The small device, which is implanted under the skin, could provide a light source for optogenetics that doesn’t require damage to the skull or brain. While optogenetics (Read more...)

DNA Origami to Trap Viruses Inside Body

Researchers at the Technical University of Munich have developed a method to create tiny virus traps that can bind viral particles and render them harmless within the body. The technique relies on DNA origami to create self-assembling hollow nanocapsules, which are lined with molecules that will bind viruses and prevent them from leaving. With a [& (Read more...)

Gene-Silencing Nanoparticles to Treat COVID-19

Researchers at City of Hope, a research center based in California, and Griffith University in Australia have collaborated to create a new experimental anti-viral therapy that can treat COVID-19. The therapeutic consists of small interfering RNA (siRNA) molecules encapsulated within lipid nanoparticles. When delivered into the bloodstream, the nano (Read more...)

Trojan Horse Virus Makes Tumors Destroy Themselves

Researchers at the University of Zurich have developed a virus-based therapy that causes a tumor to destroy itself. They modified an adenovirus, which is a common virus that typically infects the respiratory tract and which is already widely used in medicine, to deliver genetic material that codes for an anti-cancer protein. In a sneaky move, [&hel (Read more...)

New Software Helps Design DNA Nanorobots

Researchers at Ohio State University have developed new software that allows them to rapidly design and simulate DNA nanorobots. Previously, it was challenging to engineer such tiny devices, but now researchers can map out their design in minutes. DNA-based devices have significant promise as medical technologies with potential applications in drug (Read more...)

mRNA Delivery System Protects Neurons After Stroke

Researchers at the Tokyo Medical and Dental University have developed a way to deliver therapeutic mRNA to the brain, in this case to produce brain-derived neurotrophic factor (BDNF) which can protect neurons from ischemia. The researchers hope that the treatment could help patients who have suffered a stroke to achieve better outcomes by reducing (Read more...)