Tag: Genetics

Wireless Light Implant for Optogenetics Without Skull Damage

Researchers at the University of Arizona have overcome a major limitation of optogenetics with their wireless and battery-free implant that can shine light through the skull. The small device, which is implanted under the skin, could provide a light source for optogenetics that doesn’t require damage to the skull or brain. While optogenetics (Read more...)

DNA Origami to Trap Viruses Inside Body

Researchers at the Technical University of Munich have developed a method to create tiny virus traps that can bind viral particles and render them harmless within the body. The technique relies on DNA origami to create self-assembling hollow nanocapsules, which are lined with molecules that will bind viruses and prevent them from leaving. With a [& (Read more...)

Gene-Silencing Nanoparticles to Treat COVID-19

Researchers at City of Hope, a research center based in California, and Griffith University in Australia have collaborated to create a new experimental anti-viral therapy that can treat COVID-19. The therapeutic consists of small interfering RNA (siRNA) molecules encapsulated within lipid nanoparticles. When delivered into the bloodstream, the nano (Read more...)

Trojan Horse Virus Makes Tumors Destroy Themselves

Researchers at the University of Zurich have developed a virus-based therapy that causes a tumor to destroy itself. They modified an adenovirus, which is a common virus that typically infects the respiratory tract and which is already widely used in medicine, to deliver genetic material that codes for an anti-cancer protein. In a sneaky move, [&hel (Read more...)

New Software Helps Design DNA Nanorobots

Researchers at Ohio State University have developed new software that allows them to rapidly design and simulate DNA nanorobots. Previously, it was challenging to engineer such tiny devices, but now researchers can map out their design in minutes. DNA-based devices have significant promise as medical technologies with potential applications in drug (Read more...)

mRNA Delivery System Protects Neurons After Stroke

Researchers at the Tokyo Medical and Dental University have developed a way to deliver therapeutic mRNA to the brain, in this case to produce brain-derived neurotrophic factor (BDNF) which can protect neurons from ischemia. The researchers hope that the treatment could help patients who have suffered a stroke to achieve better outcomes by reducing (Read more...)

Quick and Easy CRISPR COVID Test Spots Mutations

Researchers at Nanyang Technological University, Singapore (NTU Singapore) have developed an easy to perform CRISPR-based COVID-19 test that takes only 30 minutes for the results to come in. The test, which involves dipping a paper strip into a mixture containing a nasal sample, can identify various new variants of the virus, and could be useful [& (Read more...)

Smartphone Dongle for Cancer Biomarker Measurement

Researchers at McMaster and Brock universities in Canada have developed a hand-held device that can provide rapid measurements of cancer biomarkers in blood samples. Termed an electrochemical bio‐barcode assay, the device could be used to measure a variety of health markers at home, and is similar to the devices used by patients with diabetes (Read more...)

Orbit Subretinal Delivery System for Gene Therapy: Interview with Mike Keane, CTO of Gyroscope Therapeutics

Gyroscope Therapeutics, a retinal gene therapy company, has developed the Orbit subretinal delivery system (SDS). The technology is designed to deliver therapies to the retina without the need for invasive procedures, such as vitrectomies, which involve removing the gel-like substance within the eye, or retinotomies, which involve making a hole in (Read more...)

Nanopropellers to Deliver Gene Therapy Into Cells

Researchers at the Max Planck Institute for Intelligent Systems in Germany have developed powerful nanopropellers that can be steered into the interior of cells to deliver gene therapy. The magnets that these devices, each about the size of a bacteria, are made of were created for the first time for this very task. Most powerful […]

CRISPR-Based Test to Diagnose COVID-19 in Less than One Hour

With the COVID-19 pandemic growing globally, new ways of detecting the infection is the need of the hour. University of California, San Francisco researchers have recently published a paper in Nature Biotechnology outlining their approach to diagnose COVID-19 infections from respiratory swabs using CRISPR. The test, called the SARS-CoV2 DETECTR ass (Read more...)

Artificial Self-Assembled Blood Vessels

A team of researchers headed by groups at University of Nottingham and Queen Mary University London have come up with a smart material that forms into new blood vessels. Made out of graphene oxide and a protein, the material is 3D printed and naturally forms into tubular shapes that are very similar to blood vessels. […]

New Customizable Bio-Ink for Printing Organs, Tissues

3D printing of tissues and organs requires a bio-ink that can host the living cells that are required for every unique application. A viable construct requires an extracellular matrix that will have the right mechanical and biochemical properties for the intended cells. Researchers at Rutgers University believe they’re on track to being able (Read more...)