Scientists at Johns Hopkins used a combination of molecular labeling and imaging techniques to create a three-dimensional map of the blood vessels in the mouse skull. Their approach also reveals niches where stem cell populations lurk, which could help researchers to understand how blood vessels and cells behave in various states of disease or inju (Read more...)
Tag: Pathology
Imaging Technique Generates 3D Images of Bacteria for Antibiotic Susceptibility Testing
Researchers at the University of Connecticut have developed a highly sensitive imaging sensor that can rapidly and accurately monitor bacterial growth. The technique involves shining laser light through a bacterial sample and taking images at multiple orientations, before reconstructing the diffracted light patterns, to produce a 3D image of the ba (Read more...)
Multistep Lateral Flow Devices Perform Advanced Assays
Researchers at Georgia Tech have developed a lateral flow test platform that can perform advanced assays that would otherwise require a laboratory. By controlling the flow of liquid through the lateral flow test, the research team designed it so that it can perform advanced multistep assays that do not require sophisticated lab equipment and signif (Read more...)
3D Microscopy of Whole Organs with Micrometer Detail
A team of scientists at Umeå University in Sweden came up with a way to create complex 3D maps of whole organs in incredible detail. The approach involves embedding a whole organ in agarose, a stiff gel matrix, and then using this support matrix to section the tissue into cm3 chunks. These chunks are the […]
Optical Fiber Imaging for Next-Generation Endoscopes
Researchers at the University of Exeter in England have developed a technique to image tissues through an ultrathin optical fiber, potentially allowing for high-resolution imaging of single cells within the body. The optical fibers are as thin as a human hair, and could lead to tiny endoscopes that can be inserted into human tissues to […]
Electrochemical Device Detects SARS‑CoV‑2 Spike Protein in 1 Second
Researchers at the University of Florida and the National Chiao Tung University in Taiwan have developed a microfluidic device that can detect the SARS‑CoV‑2 spike protein in a saliva sample within one second. The electrochemical device employs antibodies against the spike protein to detect the virus, and could allow for ultra-rapid COV (Read more...)
Phonon Probe to Image Tissues Ultrasonically at Nanoscale
Visual signs of disease can often be spotted within affected tissues, and advances in histopathology have provided clinicians with powerful diagnostic tools to spot those signs. Microscopes are the cornerstone of this trade, and although they have proven to be extremely useful, they do suffer from some limitations. They are effectively 2D imaging d (Read more...)
Ultrasonic Biopsy Needle for Larger Tissue Samples
Researchers at Aalto University in Finland have developed an ultrasonically actuated needle that can retrieve a large amount of tissue during a biopsy, without the pain and complications associated with using bigger needles. The technique could be very useful when clinicians need to obtain tissue samples for molecular tumor diagnostics, since obtai (Read more...)
Ultrasonic Biopsy Needle for Larger Tissue Samples
Researchers at Aalto University in Finland have developed an ultrasonically actuated needle that can retrieve a large amount of tissue during a biopsy, without the pain and complications associated with using bigger needles. The technique could be very useful when clinicians need to obtain tissue samples for molecular tumor diagnostics, since obtai (Read more...)
Microneedle Patch with Fluorescent Nanolabels Detects Antibodies in Skin
Researchers at the Washington University in St. Louis have developed a microneedle patch that can help to detect small amounts of antibodies in interstitial fluid. The painless technology could provide an alternative to blood draws for antibody tests, such as those used in the COVID-19 response. The new technology overcomes a bottleneck with many m (Read more...)
Siemens epoc NXS Host Mobile Computer Cleared to Help Point of Care Blood Testing
Siemens Healthineers won both EU and US regulatory approval to introduce its epoc NXS Host mobile computer for the epoc Blood Analysis System. The Android smartphone provides an app-based intuitive interface that replaces the older interface that had over two dozen physical buttons and a relatively low resolution screen. The accompanying app is des (Read more...)
Paper Test for Quick Diagnosis of COVID-19
Researchers at the University of Illinois have developed a paper-based electrochemical diagnostic test for COVID-19 that can provide a result in just five minutes. The inexpensive test relies on the conductive properties of graphene and gold, and contains gold nanoparticles covered in sensitive nucleic acid probes that can bind to RNA from the SARS (Read more...)
CRISPR Test Uses Cell Phone Camera to Detect SARS-CoV-2
Researchers at UC Berkeley have developed a rapid test for SARS-CoV-2 that uses an enzyme to cleave viral RNA, initiating a fluorescent signal that can be detected using a smartphone camera, and which can provide a quantitative measurement of the level of viral particles in the sample. The test produce a result in as little […]
Rapid PCR Chip for Infectious Disease Diagnostics
Researchers at Imperial College London have developed a tiny lab-on-a-chip that can perform PCR diagnostics in just a few minutes. Usually requiring bulky and expensive lab equipment, PCR is a gold standard diagnostic test for a variety of infectious pathogens, including bacteria and viruses, such as SARS-CoV-2. The new testing device is 1 cm in [& (Read more...)
Paper-Based Device Rapidly Detects Antibiotic-Resistant Bacteria
Researchers at Binghamton University have developed a device that can rapidly detect certain types of antibiotic-resistant bacteria. The device uses paper as a substrate, and allows a user to rapidly test the effects of specific antibiotics on patient bacterial samples. It measures the effects of antibiotics on the electron transfer bacteria, provi (Read more...)
Rapid Identification of Antibiotic-Resistant Infections: Interview with Jong Lee, CEO at Day Zero Diagnostics
Antibiotic resistance is a growing concern, with some predictions suggesting that routine surgery could be unacceptably risky in a future where many antibiotics have become obsolete. Part of the problem lies in the time it takes clinicians to diagnose an antibiotic-resistant infection. Current techniques involve lab technicians culturing a bacteria (Read more...)
Tiny Robots Walk Through Colon to Deliver Drugs, Sample Tissue
Delivering drugs to internal organs and tissues is usually achieved through ingested medications, but these are often diluted and intercepted before enough can reach the intended destination. Targeted delivery is preferred but usually very difficult to accomplish, particularly when there’s a lot of fluids and movement. This is the case with t (Read more...)
Robotic Probe for Semi-Autonomous Colonoscopies
Researchers at the University of Leeds in the UK have developed a robotic system that can assist a physician or nurse to perform a colonoscopy. The system uses magnets to guide a probe through the body, and its developers claim that the approach is easier for operators and less painful and uncomfortable for patients. The […]
(Read more...)Cell Culture System Mimics Effects of Lung Motion on Cancer Metastases
Researchers at Purdue University have developed a cell culture system to examine the effects of lung motion on breast cancer metastases. The system uses magnets to provide a stretching force on a 3D culture of breast cancer cells, and the researchers hope that the technology could lead to new insights into metastases and how to […]
Sensor Rapidly Detects SARS-CoV-2, Antibodies, and Inflammatory Markers
Researchers at Caltech have developed a low-cost multiplex test that can rapidly provide three different types of data on COVID-19. The test can detect the presence of SARS-CoV-2, antibodies against the virus (potentially indicating a level of immunity), and inflammatory markers that could indicate the severity of COVID-19. Using blood or saliva, t (Read more...)