Scientists at Duke University have developed a ‘nanorattle’ system that allows for the detection of mRNA biomarkers of cancer. The tiny structures consist of gold nanospheres with a surrounding silver nanocage, forming the so-called rattle. The nanorattles are also loaded with light scattering dyes called Raman reporters. When illuminat (Read more...)
Tag: Pathology
Point of Care Rapid PCR Test
Columbia University scientists and collaborators at Rover Diagnostics have created a rapid PCR test that can be used at the point of care. Weighing in at two pounds, the portable device can rival the sensitivity and accuracy of traditional lab-based PCR testing equipment, but providing results in as little as 23 minutes. The new device […]
Dissociating Tissue into Single Cells Using Electric Fields
A team of scientists at Brown University has developed a technique that allows them to rapidly dissociate a tissue sample into individual cells. The approach involves placing a tissue sample, such as a tumor biopsy, between two electrodes. Electric field fluctuations then help to pull the cells in alternating directions, eventually culminating in t (Read more...)
Typhoid Detection Technique Improves Diagnostic Sensitivity
A team at the University of California Davis Health working with international collaborators have developed a new technique to detect typhoid and estimate its incidence in populations over time. The approach requires only a drop of blood from a finger prick and involves measuring levels of antibodies against two antigens: Hemolysin E (Hlye) and Sal (Read more...)
Microfluidic Chip Models Inflammatory Intestinal Disease
Researchers at Harvard’s Wyss Institute have modeled Environmental Enteric Dysfunction (EED), a childhood inflammatory intestinal disease, on a microfluidic chip and gained new insights into the genetic changes underlying the condition. This is the first in vitro model of the disease, and highlights the power of organ on a chip systems to pro (Read more...)
Spinning Disc Separates Circulating Tumor Cells from Blood
A team of researchers at Daegu Gyeongbuk Institute of Science & Technology in Korea created a centrifugal system to separate circulating tumor cells from blood samples. Resembling a DVD, the device separates the cells using the centrifugal force created when it is spun. A layer of white blood cells and circulating tumor cells is formed [&hellip (Read more...)
Photonic Technique for Deeper Fluorescent Sensors
Researchers at MIT have developed a method that lets them read the signal from fluorescent sensors that are as deep as 5.5 centimeters in tissue. Previously, it was very difficult to get a good signal from a fluorescent sensor placed that deep, as fluorescence emitted by the tissue itself would muddy the signal. The new […]
Perfusion Machine Restores Donor Liver for Transplant
Clinical researchers at the University of Zurich in Switzerland have created a perfusion machine to store donor livers before transplant. We originally reported on the machine back in 2020, but now the team has announced that they stored and treated a damaged liver in the machine, which would ordinarily not be suitable for transplantation. After [& (Read more...)
Advanced Multi-Organ Chip for Personalized Medicine
Researchers at Columbia University School of Engineering and Applied Science developed an advanced organ-on-a-chip system that incorporates heart, bone, liver, and skin tissue in independent niches that are linked with simulated vascular flows. The system even includes immune cells that circulate within the simulated vasculature. The technology rep (Read more...)
3D Microscope Quickly Reveals Features in Living Tissues
A team at Columbia University created a 3D microscope that can be used to image living tissues. The technology can help clinicians identify features in tissues without the need for histology or biopsies, and could be invaluable during surgical procedures. One application involves a surgeon using the scope to identify the boundaries of a tumor [&hel (Read more...)
Magnetic Tentacle Robot Travels Deep into Lungs
Researchers at the University of Leeds in the UK have created a magnetic “tentacle robot” that is just 2 mm in diameter, which they hope will be able to navigate through some of the smallest airways in our lungs. At present, a bronchoscope is used to investigate the lungs, but this cannot pass into very […]
Lymphoid Follicle Chip Models Complex Immune Responses
Researchers at the Harvard Wyss Institute have created a microfluidic chip that contains lymphoid follicle-like structures, allowing them to model complex immune responses to various pathogens and vaccines. The breakthrough could let scientists to more comprehensively probe the complex workings of the immune system. Lymphoid follicles are found in (Read more...)
Automatic Blood Smear Preparation for Reliable Malaria Diagnosis
Researchers at Cambridge and Bath universities in the UK, along with colleagues at the Ifakara Health Institute in Tanzania, have created two devices, called autohaem, that assist in creating blood smears, a common technique for diagnosing malaria. A blood smear involves manually smudging a drop of blood across a microscope slide to allow observati (Read more...)
Magnetic-Plasmonic Hybrid Nanoparticles Isolate Lysosomes from Cells
Researchers at the Japan Advanced Institute of Science and Technology have developed a method to isolate intact lysosomes from cells. The technique is rapid and produces samples of high purity. Lysosomes are the garbage-disposal organelles within a cell, and they are involved in numerous diseases, from lysosomal storage diseases to autoimmune disor (Read more...)
Optical Biopsy to Spot Tumors Among Healthy Tissue
Researchers at Orel State University in Russia have developed a biopsy system that can distinguish between healthy and cancerous tissue in many clinical cases. The device is designed to address the difficulties that clinicians may experience when trying to obtain a biopsy of a liver tumor, where it can be difficult to know if the […]
Pop-Up Sensors Measure Electronic Signals in Cardiac Cells
Researchers at University of California San Diego have developed a tiny ‘pop-up’ sensor that can measure the electronic signals propagating inside cardiac cells. The technology consists of tiny spike-like protrusions that can penetrate cell membranes without causing damage, and which can detect electrical signals within individual cells (Read more...)
Soft X-Ray Tomography for Quick 3D Imaging of Cell Organelles
Researchers at Heidelberg University in Germany used an imaging technique called soft X-ray tomography to obtain highly detailed 3D images of the interior of cells, including changes that occur when the cell is infected with SARS-CoV-2. The approach can provide a high-resolution 3D image in minutes, which is much faster than other microscopy techni (Read more...)
3D Blood Vessel Map Reveals Location of Stem Cells
Scientists at Johns Hopkins used a combination of molecular labeling and imaging techniques to create a three-dimensional map of the blood vessels in the mouse skull. Their approach also reveals niches where stem cell populations lurk, which could help researchers to understand how blood vessels and cells behave in various states of disease or inju (Read more...)
Imaging Technique Generates 3D Images of Bacteria for Antibiotic Susceptibility Testing
Researchers at the University of Connecticut have developed a highly sensitive imaging sensor that can rapidly and accurately monitor bacterial growth. The technique involves shining laser light through a bacterial sample and taking images at multiple orientations, before reconstructing the diffracted light patterns, to produce a 3D image of the ba (Read more...)
Multistep Lateral Flow Devices Perform Advanced Assays
Researchers at Georgia Tech have developed a lateral flow test platform that can perform advanced assays that would otherwise require a laboratory. By controlling the flow of liquid through the lateral flow test, the research team designed it so that it can perform advanced multistep assays that do not require sophisticated lab equipment and signif (Read more...)