Gastrointestinal adverse effects remain a key barrier to continued use of these agents, with slower dose titration emerging as a strategy to improve tolerability and adherence. Medscape News Europe
Tag: Diabetes & Endocrinology
Myth of the Month: GLP-1s Have Many Dangerous Side Effects
Dr Paauw debunks concerns about thyroid cancer, suicide, and pancreatitis. Medscape Internal Medicine
Vascular Complications Tied to Poor CRC Outcomes in Diabetes
In patients with colorectal cancer undergoing major resection surgery, a greater severity of diabetes-related vascular complications is linked to poorer postoperative outcomes, including mortality. Medscape News UK
Eye Condition Risk Elevated With Semaglutide, but Still Low
New VA database study is the latest to find a small but significant increased risk for nonarteritic anterior ischemic optic neuropathy. Medscape Medical News
Mary Tyler Moore Initiative Combats Diabetic Retinal Disease
Moore’s widower, S. Robert Levine, MD, launched the nonprofit in his famous wife’s memory to advance research and accelerate treatment. Medscape Medical News
Secukinumab Fails to Show Benefit in Graves’ Orbitopathy
Secukinumab does not show greater clinical efficacy than placebo in patients with moderate-to-severe Graves’ orbitopathy, according to the ORBIT study. Medscape News UK
Veligrotug Shows Promise for Treating Thyroid Eye Disease
The THRIVE and THRIVE-2 clinical trials showed significant improvements in proptosis and diplopia in active as well as chronic thyroid eye disease, earning FDA Breakthrough Therapy designation. Medscape Medical News
MHRA Approves First UK Treatment for Thyroid Eye Disease
The Medicines and Healthcare products Regulatory Agency has approved teprotumumab, the first treatment to be licensed in the UK for adults with thyroid eye disease. Medscape News UK
EMA Recommends Tepezza for Severe Thyroid Eye Disease
Teprotumumab is a fully human IgG1 monoclonal antibody that inhibits tissue inflammation and remodeling. Medscape Medical News
Cardiac to Kidney Care, Standards of Care Offer New Take
Dr Anne Peters concludes her discussion of the ADA Standards of Care with a look at sections on kidney care, pregnancy care, and cardiovascular disease management in patients with diabetes. Medscape Diabetes & Endocrinology
Viridian Shares Soar After Latest Trial Success for Thyroid Eye Disease Drug
Viridian Therapeutics’ experimental treatment for chronic thyroid eye disease (TED) significantly reduced symptoms such as double vision and eye bulging in a late-stage… Reuters Health Information
Diagnosing and Managing Thyroid Eye Disease
A joint presentation by an endocrinologist and ophthalmologist reviewed best practices for managing thyroid eye disease, including when to refer to an ophthalmologist and what tests to run. Medscape Medical News
Diabetic Kidney Disease Therapies Keep on FLOWing
The FLOW study cements semaglutide’s position as a new therapeutic pillar for diabetic kidney disease, but what are its implications for primary care? Medscape Diabetes & Endocrinology
Can Thyroid Dysfunction Cause Hormonal Imbalance?
When to suspect that thyroid dysfunction is responsible for a hormonal imbalance, and how to determine whether it is the cause. American Thyroid Association
CGM Associated With Lower Retinopathy Risk in T1D
The use of continuous glucose monitoring (CGM) was linked to a reduced risk for diabetic retinopathy, a debilitating complication in adults with type 1 diabetes. Medscape Medical News
Even an Hour’s Walk a Week Lowers Risk in Type 2 Diabetes
Leisure time activity equivalent to less than 1.5 hours’ walking time per week may be enough to substantially reduce the risk for neuropathy and nephropathy in type 2 diabetes, say Danish researchers. Medscape Medical News
New Approaches for Diabetic Keratopathy in the Eye?
Findings also have implications for treating other diabetes-related wound healing conditions such as foot ulcers. Medscape Medical News
Aging and Type 1 Diabetes: ‘Complete Picture’ 40 Years On
The Diabetes Control and Complications Trial (DCCT) and its follow-on observational study EDIC continue to provide new insights into type 1 diabetes as the study participants age. Medscape Medical News
Alarm Bells Ring for Eye Issues in Kids With Type 2 Diabetes
Annual screening with fundus photography could allow for early detection and treatment of diabetic retinopathy in children diagnosed with type 2 diabetes. Medscape Medical News
Aflibercept Not for Prevention in Early Diabetic Retinopathy
‘Preventive treatment with anti-VEGF [such as aflibercept] for eyes with nonproliferative diabetic retinopathy generally is not a strategy that is warranted,’ says study investigator. Medscape Medical News