Source: NICE
Area: Evidence > Guidelines
NICE has published guidance (Technology Appraisal Guidance 237) recommending against the use of ranibizumab within the NHS for the treatment of visual impairment due to diabetic macular oedema. Those who are currently receiving this treatment should have the option to continue treatment until they and their clinicians consider it appropriate to stop.
The full guidance (please see link below) discusses the evidence considered by the Appraisal Committee. This notes that the manufacturer's model resulted in an incremental cost effectiveness ratio (ICER) of ranibizumab versus laser photocoagulation of £30,277 per QALY gained; this was however likely to be an underestimation of the true value as the model was reliant on several implausible assumptions.
The Committee concluded that a model that relied on a combined set of plausible assumptions would be certain to produce an ICER that substantially exceeded the acceptable range, and it was ...
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