Is memantine effective in the treatment of nystagmus?

Source: Regional Drug and Therapeutics Centre
Area: Evidence > Medicines Q & A
Nystagmus is a disorder of the eyes in which fast, uncontrollable movements of the eyeball occur. Usually, vision is not affected, and the patient may not be aware of the movements. Some patients, particularly in cases of acquired nystagmus, can experience blurred vision and oscillopsia which can interfere with their quality of life. Nystagmus may have a variety of causes including congenital, trauma, and multiple sclerosis (MS). A number of drug treatment strategies, including antiepileptics, botulinum toxin, alcohol, and tetrahydrocannabinol have been used for treatment of acquired nystagmus, although no cure exists. Non-pharmacological treatment can include use of prisms and filters, or surgery.    Memantine is an NMDA receptor antagonist licensed for the treatment of moderate to severe Alzheimer's Disease. Its use as a treatment for nystagmus is an unlicensed indication.