Source: Arch Dermatol
Area: News
Ocular adverse effects (AEs) have been reported with the use of isotretinoin, resulting mostly from changes to the eyelids and the surface of the cornea or lacrimal abnormality that leads to dry eye. There have been reports in the literature of blepharoconjunctivitis, keratoconjunctivitis sicca, cutaneous photosensitivity, contact lens intolerance, refractive changes, papilledema, pseudotumor cerebri, and abnormal retinal function. This retrospective cohort study assess ed the risk of ocular AEs in a large and unselected population of isotretinoin users, to describe the most common AEs, and to evaluate the period of highest risk
Researchers obtained data from the electronic medical databases of a large health maintenance organisation in Israel on 14,682 adolescents and young adults who were new users of isotretinoin for acne and two age- and sex-matched comparison groups (isotretinoin-naive patients with acne and acne-free patients). The main outcome measures were ocular ...
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