Source: Canadian Agency for Drugs and Technologies in Health (CADTH)
Area: News
This Canadian review examined the clinical effectiveness, safety and economic literature on fusidic acid to help inform a funding decision.
The evidence on the clinical effectiveness and safety of fusidic acid for eye infections was limited to three lower quality RCTs which noted the following:
. Short term (7 day) treatment with topical fusidic acid resolved clinical signs and symptoms of conjunctivitis or chronic blepharitis in 76% to 91% of patients compared to 73% to 93% of those who received other topical antibiotics.
. The cure rate between antibiotics was not statistically significantly different for fusidic acid versus tobramycin, norfloxacin or ciprofloxacin.
. Ocular discomfort and irritation were the most frequently reported adverse events. The incidence of adverse events was similar for fusidic acid versus ciprofloxacin or tobramycin, and higher for norfloxacin versus fusidic acid.
. No ...
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