MATrX-1, a phase 3 trial of trabodenoson for the treatment of primary open-angle glaucoma or ocular hypertension, failed to achieve its primary endpoint of superiority in reduction of IOP compared with placebo at all time points, according to an Inotek Pharmaceuticals press release.The randomized, double-masked, placebo-controlled trial assessed the safety, efficacy and tolerability of three doses of trabodenoson in 303 subjects. Patients’ IOP was measured on days 14, 28, 42 and 84 at four time points during each of these days: 8 a.m., 10 a.m., 12 p.m. and 4 p.m. (Read more...)
Author: Healio ophthalmology
Dextenza meets secondary endpoint in phase 3 trial
A phase 3 clinical trial of Dextenza for the treatment of post-surgical inflammation and pain has shown successful secondary endpoint results, according to a press release from Ocular Therapeutix. The bioresorbable intracanalicular insert is designed t…
Positive topline results announced for phase 3 trial of Seciera for dry eye
Seciera for the treatment of dry eye disease has met primary and key secondary endpoints in a phase 3 confirmatory clinical trial, according to a Sun Pharma press release.The 12-week, multicenter, randomized, double-masked, vehicle-controlled trial inc…
Bag-in-the-lens a forgiving technique if explantation is needed
We present an example of a patient who underwent bag-in-the-lens cataract surgery with a monofocal lens. Six weeks postoperatively she came back complaining of visual disturbance due to residual astigmatism of –1.75 D and told us she strongly wished to be without glasses or contact lenses. Because the BIL technique offers a relatively easy method for IOL exchange, we offered to exchange the lens for a toric IOL. Surgical technique
Trefoil Therapeutics working with NIH to develop compound for Fuchs’ dystrophy
Trefoil Therapeutics is working with the National Institutes of Health to complete investigational new drug activities for a compound to treat Fuchs’ endothelial corneal dystrophy, according to a news release.Trefoil is collaborating with the NIH’s National Center for Advancing Translational Sciences to accelerate the development of the company’s lead compound, TTHX1114.
VIDEO: Both art and science involved in choosing enhancement approach
At OSN New York, Douglas A. Katsev, MD, discusses the options for surgeons who must follow up on presbyopic IOL implantation with enhancements. According to Katsev, the best way to avoid the need for enhancement is to employ good technicians, to be cur…
VIDEO: Topography-guided LASIK offers potential to increase corneal optics
At OSN New York, Alan Faulker, MD, lists the benefits of topography-guided LASIK, including the potential to increase corneal optics and overall eye performance. However, there are still unknowns, such as the role of epithelial thickness and remodeling…
Physician, heal thyself, but be aware of the antitrust laws
From international law firm Arnold & Porter LLP comes a timely column that provides views on current regulatory and legislative topics that weigh on the minds of today’s physicians and health care executives.
PUBLICATION EXCLUSIVE: 2016 Year in Review: Miracles do happen
For me personally, the drought of seeing the Chicago Cubs actually win the World Series and seeing the joy of my patients who have suffered even longer than me is just the icing on the cake to a great year for the ophthalmic industry in 2016. Thirteen years of having only one topical dry eye medication finally ended with an alternative for those 33 million-plus patients suffering from chronic dry eye disease. Patients with progressive keratoconus and corneal ectasia finally have a treatment other than corneal transplantation. Those patients with (Read more...)
VIDEO: Intracameral dilation achieves stable, predictable pupillary dilation
At Hawaiian Eye 2016, Ian Conner, MD, PhD, discusses the advantages of dilating patients’ pupils intracamerally before anterior segment surgery. Conner said the intracameral method sustains dilation throughout surgery and may be cost-effective when used routinely.
VIDEO: Speaker explores current trends in endophthalmitis research
At Hawaiian Eye 2016, Francis S. Mah, MD, explores the trends in research of drugs and delivery methods for preventing postoperative endophthalmitis.
VIDEO: Methods vary in correcting ‘refractive misses’
At Hawaiian Eye 2016, John A. Hovanesian, MD, discusses a step-by-step process meant to address concerns of unhappy patients after refractive cataract surgery. A variety of tools are available to rectify “refractive misses,” he said, with the refractiv…
VIDEO: Topography, tomography yield accurate measurements for irregular corneas
At Hawaiian Eye 2016, Jack T. Holladay, MD, MSEE, talks about the advantages of combining topography, tomography and keratometry measurements to arrive at more precise measurements for predicting effective lens position in irregular corneas
VIDEO: White dot syndrome identity helps determine how aggressively to treat disorder
At Hawaiian Eye, Thomas A. Albini, MD, discusses the spectrum of entities identified as white dot syndrome and their causes. Certain entities can result in severe vision loss due to macular scarring, macular fibrotic scarring, atrophy and chronic choro…
VIDEO: Preoperative planning, technology choice key to correcting residual refractive error
At Hawaiian Eye, William B. Trattler, MD, relates enhancement techniques for patients with residual refractive error after cataract surgery. The choice of enhancement procedure varies based on amount of residual refractive error, history of prior corne…
VIDEO: Surgeon prefers prophylactic intracameral cefuroxime over antibiotic drops
At Hawaiian Eye, Eric D. Donnenfeld, MD, discusses the effectiveness of intracameral antibiotics in preventing endophthalmitis after cataract surgery. Donnenfeld shared a study showing a five-fold reduction in cases of the infection when intracameral cefuroxime is used instead of antibiotic drops.
VIDEO: Speaker discusses future of IOL power selection
At Hawaiian Eye, Eric D. Donnenfeld, MD, talks about the next generation of IOL power calculations, which are non-traditional formulas that he says will yield better visual outcomes.
PUBLICATION EXCLUSIVE: What measures are you taking to prepare for MIPS?
I wish I could provide an intelligent response to this question. My office manager has been busily educating herself regarding the requirements and (hopefully) getting prepared to implement the required procedural infrastructure. That being said, my level of involvement in the process remains at this superficial level, at least for now. Hopefully, my confidence in my administrative staff to “get it right” will be well founded, or we will be in for a bit of a rude awakening.
Top 10 ophthalmology articles of 2016
Ophthalmology news in 2016 ran the gamut from important drug trials and approvals to studies regarding the cause and treatments of a multitude of ailments.Here are the top 10 most read stories in ophthalmology this year on Healio.com:
PUBLICATION EXCLUSIVE: Medicare payment adjustments to be based on quality and cost
In October, the CMS released the final rule to implement the Medicare Access and CHIP Reauthorization Act of 2015, effectively ending the SGR formula and introducing a new payment adjustment path for ophthalmologists who serve Medicare patients.The Med…