An add-on agent designed to boost drugs that treat age-related macular degeneration failed to show any benefit in two phase 3 trials, so the sponsor halted both trials. Medscape Medical News
Author: Medscape
Gene Therapy: Medical Progress Has a Price, Says Ethicist
Ethicist Art Caplan discusses progress in gene therapy research and the need for medical professionals and regulators to tolerate appropriate risk. Medscape Business of Medicine
HLA-B27 Status Linked to Poor Outcomes in JIA After 18 Years
HLA-B27 positivity is linked to higher odds of non-remission in patients with juvenile idiopathic arthritis at 18 years after disease onset, with the odds being higher in men than in women. Medscape News UK
EMA Recommends Ryjunea for Pediatric Myopia
The atropine-based eye drop is designed to slow myopia progression in children. Medscape Medical News
Semaglutide Use Linked to Risk for Vision Loss in Diabetes
Patients with diabetes who take semaglutide are at increased risk for NAION compared with patients who do not use GLP-1 RAs to control their blood sugar, a new study finds. Medscape Medical News
The Ethical Consequences of the New Administration
Ethicist Art Caplan discusses the ethical consequences of the new administration. Medscape Business of Medicine
Cataract Surgery May Help Prevent Falls and Fractures
Cataract extraction with intraocular lens insertion is associated with reduced odds of falls and major injuries in older adults with age-related cataracts, a new study finds. Medscape Medical News
Multiple Drug Classes Can Up Risk for Floppy Iris Syndrome
Researchers find new drug associations with floppy iris syndrome, including alpha-1 blockers, atypical antipsychotics, tricyclic antidepressants, and, in women, brinzolamide and salbutamol. Medscape Medical News
Multivitamins Slow Biological Aging in a Large Trial
Dr JoAnn Manson discusses recent data on the use of multivitamin supplementation to slow aging, presented at the American Heart Association’s EPI/Lifestyle 2025 Scientific Sessions. Medscape Ob/Gyn
Ethicist Supports Assisted-Suicide Policies—With Safeguards
Ethicist Art Caplan discusses considerations regarding assisted-suicide laws. Medscape Business of Medicine
Study: Ab Interno Canaloplasty for Glaucoma Effective, Safe
A real-world analysis finds minimally invasive canaloplasty for glaucoma lowers intraocular pressure by 20% or more in half the patients, with few complications. Medscape Medical News
Survey Examines Eyewash Use in Hay Fever
Eyewash usage is prevalent among patients with hay fever, with factors such as younger age and use of contact lenses linked with higher usage, a recent study shows. Medscape Medical News
GLP-1s Are Crazy Effective — Just Not Cost-Effective
We know they are expensive, but isn’t the cost recouped by the healthcare savings? Dr F. Perry Wilson explains. Medscape
Tularemia: A Rare but Nationally Notifiable Disease
In the US, most human cases of tularemia historically have been arthropod borne, transmitted by the bite of an infected tick or deer fly. Medscape Pediatrics
Air Pollution Ups Risk for Ocular Complications in Adults
High levels of exposure to air pollution can increase the incidence of diabetic retinopathy and glaucoma, a recent study finds. Medscape Medical News
Port System Cuts Injection Burden in Diabetic Eye Disease
Continuous administration of ranibizumab with a port delivery system provides an alternative to frequent intravitreal injections for diabetic macular edema and helps delay progression of nonproliferative diabetic retinopathy. Medscape Medical News
Night Shift: Raised Head in Bed May Worsen Glaucoma
Patients with primary open-angle glaucoma were found to have lower blood flow to the eye during sleep, which may contribute to the progression of the eye disorder. Medscape Medical News
FDA OKs First Gene Therapy Implant for a Rare Eye Disease
The FDA has approved a new gene therapy for macular telangiectasia type 2 (MacTel), a rare eye disease that causes vision loss. WebMD Health News
New Tool May Flag Visual Perception Problems Post-Stroke
The free tool takes 15 minutes to administer and could increase screening access for stroke survivors and fill an unmet need for health care professionals. Medscape Medical News
Can Hypertension Be Protective Against Glaucoma in Blacks?
A study of people of African ancestry confirmed myopia raises the risk for conversion to primary open-angle glaucoma, but hypertension appeared to lower the risk. Medscape Medical News