CCL19 emerges as a promising biomarker that distinguishes active disease from treatment-induced remission and may help to identify relapsing disease in patients with IgG4-related disease. Medscape Medical News
Tag: Rheumatology
Smoking May Lower Sjögren Disease Risk and Mask Pathology
Cigarette smokers have a significantly lower likelihood of being diagnosed with Sjögren’s disease, with histologic data showing less tissue damage and lower disease activity in smokers who have it. Medscape Medical News
Anifrolumab Improves Multiple Sjögren Disease Measures
Early data from the ANISE-II study show that the lupus-approved treatment may also work well in managing Sjögren disease. Medscape Medical News
Hydroxychloroquine Level Monitoring Can Boost Lupus Control
Weight-based dosing misses accounting for factors such as chronic kidney disease or chronic transaminitis, which could potentially accelerate toxicity risk or increase the risk for SLE flares. Medscape Medical News
Low-Dose Aspirin May Reduce Cardiovascular Risk in GCA
Low-dose aspirin initiated at diagnosis of giant cell arteritis is linked to a reduced probability of major adverse cardiovascular events at 1 year but also to an increased risk for major hemorrhage. Medscape Medical News
Treating IgG4-RD: How Far Will B-Cell Drugs Take the Field?
Post hoc analyses of pivotal MITIGATE trial show broad efficacy across patient subgroups with differing organ involvement and clinical characteristics. Medscape Medical News
Pediatric Rheumatologist Explains Updated ACR JIA Guidelines
The new draft guidelines favor earlier DMARD therapy with ‘much decreased reliance on glucocorticoids that have several side effects in growing children,’ said rheumatologist Susan Shenoi, MS. Medscape Medical News
PET/CT Can Catch Cranial GCA Missed by Doppler Ultrasound
Digital FDG PET/CT can pick up cranial giant cell arteritis that may be missed on ultrasound because of a lack of trunk large-vessel involvement. Medscape Medical News
Dry Eye Disease May Occur Years Before Autoimmune Disease
Dry eye disease affects many people across different autoimmune diseases, ranging in prevalence from about 23% to 81%, and appears about 3 years before diagnosis, a study finds. Medscape Medical News
FDA Makes Ianalumab Breakthrough for Sjögren Disease
Results from two clinical trials on ianalumab for Sjögren disease show favorable safety and adverse event outcomes, contributing to this designation. Medscape Medical News
FDA Makes Ianalumab a Breakthrough Therapy for Sjögren’s
Results from two clinical trials on ianalumab for Sjögren disease show favorable safety and adverse event outcomes, contributing to this designation. Medscape Medical News
Advice on Recognizing and Managing Sjӧgren Disease
Dr Nancy Carteron urges clinicians to learn to recognize how Sjӧgren disease could be hiding in plain sight and why early care is more essential than ever. Medscape
Advice on the Challenges in Managing Sjögren Disease
Dr Teja Kapoor urges early-career clinicians not to underestimate Sjögren’s disease, which requires thorough testing and multidisciplinary collaboration. Medscape
Overcoming Barriers in Sjögren Disease Care
Dr Teja Kapoor explores how cultural sensitivity and awareness can overcome barriers to timely Sjögren disease management in diverse communities. Medscape
Biosimilars for Retina and Inflammatory Disease Get EMA Nod
The European regulator has recommended marketing approval for Ranluspec and Gotenfia after studies confirm their safety, efficacy, and cost-effectiveness compared with reference drugs. Medscape News Europe
Biosimilars for Retina and Inflammatory Disease Get EMA Nod
The European regulator has recommended marketing approval for Ranluspec and Gotenfia after studies confirm their safety, efficacy, and cost-effectiveness compared with reference drugs. Medscape News Europe
Childhood Sjögren Disease Tied to Distinct Disease Patterns
Patients with childhood-onset Sjögren disease show distinct trajectories for disease activity and symptoms, with a notable proportion having an increased risk for lymphoma and early glandular damage. Medscape Medical News
Which Diagnostic Steps Help Spot Sjögren Syndrome Early?
Early recognition of Sjögren syndrome is essential because timely diagnosis and coordinated follow-up reduce systemic complications, including the risk for lymphoma. Medscape News UK
Systemic Therapy for Sjögren Closer With Phase 3 Success
Current treatment options have been limited to symptom control. Telitacicept, a novel fusion protein, and ianalumab, a monoclonal antibody, demonstrate improvement in disease activity. Medscape Medical News
Tocilizumab May Be Better Than MTX for GCA at 1 Year
At week 52 in a randomized, controlled trial, results suggest that tocilizumab is more effective than methotrexate in maintaining remission and preventing relapse. Medscape Medical News