The Singapore 5-Fluorouracil Trial: Intraocular Pressure Outcomes at 8 Years – Corrected Proof

Objective: To report the 8-year outcomes of Asian subjects who underwent trabeculectomy augmented by intraoperative 5-fluorouracil (5-FU) or placebo. Design: Retrospective review of a randomized controlled trial. Participants: Subjects with primary open-angle or angle-closure glaucoma. Methods: Study subjects were prospectively followed up for 3 years. After the last subject recruited had completed 8 years of follow-up, the charts of all subjects were reviewed to capture data from the year 3 visit onward. Kaplan–Meier survival function with Cox regression was performed to identify risk factors associated with trabeculectomy failure at 8 years. Main Outcome Measures: The primary outcome was trabeculectomy failure (Read more...)

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