Purpose: To evaluate the outcomes of macular hole (MH) surgery with 3-day prone positioning in highly myopic eyes and to compare them with those from non–highly myopic eyes.Design: Retrospective nested case-control study from a cohort of 496 consecutive patients (496 eyes) who underwent surgery for MH.Participants: Forty-seven highly myopic eyes (with axial length >26 mm) were included in the study group and were matched for MH size and duration of symptoms with 47 non–highly myopic control eyes selected from the same cohort.Methods: All patients underwent pars plana vitrectomy, internal limiting membrane peeling, and 17% hexafluoroethane gas filling. Patients then were (Read more...)
Author: Ophthalmology
The Use of Bowman’s Layer Vertical Topographic Thickness Map in the Diagnosis of Keratoconus – Corrected Proof
Purpose: To evaluate the use of Bowman’s layer (BL) vertical topographic thickness maps in diagnosing keratoconus (KC).Design: Prospective, case control, interventional case series.Participants: A total of 42 eyes: 22 eyes of 15 normal subjects and 20 eyes of 15 patients with KC.Intervention: Bowman’s layer 2-dimensional 9-mm vertical topographic thickness maps were created using custom-made ultra high-resolution optical coherence tomography.Main Outcome Measures: Bowman’s layer average and minimum thicknesses of the inferior half of the cornea, Bowman’s ectasia index (BEI; defined as BL minimum thickness of the inferior half of the cornea divided by BL average thickness of the superior half of (Read more...)
Lacrimal Gland Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma: Genomic Profiles, Gene Fusions, and Clinical Characteristics – Corrected Proof
Purpose: To study genetic alterations in lacrimal gland pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (Ca-ex-PA) with focus on copy number changes and expression patterns of the translocation target genes PLAG1, HMGA2, and CRTC1-MAML2 i…
The Neovascular Age-Related Macular Degeneration Database: Multicenter Study of 92 976 Ranibizumab Injections: Report 1: Visual Acuity – Corrected Proof
Purpose: To study real-world ranibizumab therapy for treatment-naïve eyes with neovascular age-related macular degeneration (nAMD) and to benchmark standards of care.Design: Multicenter, national nAMD database study.Participants: A total of 92 976 tre…
Author reply – Corrected Proof
First, We really appreciate Huisingh and McGwin’s interest in our recent publication regarding the study of suppression in patients with anisometropic amblyopia. However, the concerns they raise in their recent correspondence are not directly relevant to our study. The aim of our study was not to measure suppression before and after occlusion therapy. Rather, measurements of suppression, stereopsis, and visual acuity were made in observers with amblyopia (cases) and age-matched observers without amblyopia (controls). For a number of measurements, visual acuity was decreased in the nondominant eye of each control using optical defocus so that it matched the amblyopic eye (Read more...)
Quantitative Measurement of Interocular Suppression in Anisometropic Amblyopia – Corrected Proof
We read with great interest the recently published study by Li et al and would like to provide feedback on a several issues related to their methodology, statistical analysis, and sample selection. This study is described as both a case-control study …
Three-Dimensional Assessment of Vascular and Perivascular Characteristics in Subjects with Retinopathy of Prematurity – Corrected Proof
Purpose: To study vascular features detected with spectral domain optical coherence tomography (SD-OCT) in subjects undergoing retinopathy of prematurity (ROP) screening.Design: Cross-sectional study.Participants and Controls: Fifty-seven premature neo…
Refractive Changes after Pharmacologic Resolution of Diabetic Macular Edema – Corrected Proof
Purpose: To determine precisely the mean change in refractive power induced by treatment in patients with diabetic macular edema (DME).Design: Prospective, randomized study.Participants: Fifty eyes of 50 consecutive patients with clinically significant macular edema receiving all 3 types of current state-of-the-art treatment with intravitreal antiedematous substances (ranibizumab, bevacizumab, or triamcinolone).Methods: Patients were followed up at monthly intervals and were treated following a standardized pro re nata regimen according to protocol. Best-corrected visual acuity (BCVA) was determined by certified visual acuity examiners. The refractive power of the treated eyes was determined using a push-plus technique. The change in refraction between baseline (Read more...)
Clinical and Spectral-Domain Optical Coherence Tomography Findings in Patients with Focal Choroidal Excavation – Corrected Proof
Objective: To describe the clinical and spectral-domain optical coherence tomography (SD-OCT) findings in patients with focal choroidal excavation (FCE).Design: Retrospective case series.Participants: Forty-one eyes of 38 patients with FCE identified in 2 tertiary medical centers in Korea.Methods: Clinical features, SD-OCT findings, and associated macular disorders of FCE were analyzed and detailed.Main Outcome Measures: Statistical associations among clinical features, including lesion type, size, and choroidal thickness, and frequency of association with central serous chorioretinopathy (CSC), choroidal neovascularization (CNV), and polypoidal choroidal vasculopathy (PCV).Results: Mean patient age was 50.1 years (range, 25–76 years). The mean spherical equivalent of refractive error was −3.7 diopters (Read more...)
Disparity between Visual Fields and Optical Coherence Tomography in Hydroxychloroquine Retinopathy – Corrected Proof
Purpose: American Academy of Ophthalmology recommendations for screening for hydroxychloroquine (HCQ) retinopathy advise objective measures, such as spectral-domain optical coherence tomography (SD-OCT) and multifocal electroretinography (mfERG) along …
Collaborative Retrospective Macula Society Study of Photodynamic Therapy for Chronic Central Serous Chorioretinopathy – Corrected Proof
Purpose: To assess the visual and anatomic outcomes of central serous chorioretinopathy (CSC) after verteporfin photodynamic therapy (PDT).Design: Retrospective case series.Participants: Patients with CSC who underwent PDT.Methods: Members of the Macul…
Histopathology of Streptococcus Mitis/Oralis Endophthalmitis after Intravitreal Injection with Bevacizumab: A Report of 7 Patients – Corrected Proof
Purpose: To report the histopathologic findings of a series of patients from an outbreak of Streptococcal endophthalmitis after intravitreal injection of bevacizumab prepared by a single compounding pharmacy.Design: Case series.Participants: Seven surg…
Geographic Atrophy: Clinical Features and Potential Therapeutic Approaches – Corrected Proof
In contrast to wet age-related macular degeneration (AMD), where loss of vision is typically acute and treatment leads to a relatively rapid reduction in retinal fluid and subsequent improvements in visual acuity (VA), disease progression and vision lo…
Use of Health Care Claims Data to Study Patients with Ophthalmologic Conditions – Corrected Proof
Objective: To describe what information is or is not included in health care claims data, provide an overview of the main advantages and limitations of performing analyses using health care claims data, and offer general guidance on how to report and i…
Qualitative and Quantitative Characteristics of Near-Infrared Autofluorescence in Diabetic Macular Edema – Corrected Proof
Objective: To study the characteristics of near-infrared autofluorescence (NIR-AF) imaging and its association with spectral-domain optical coherence tomography (SD-OCT) findings and logarithm of the minimal angle of resolution (logMAR) visual acuity (VA) in diabetic macular edema (DME).Design: Retrospective, observational, cross-sectional study.Participants: One hundred twenty-one consecutive eyes of 87 patients with center-involved DME for whom NIR-AF and SD-OCT images of sufficient quality were obtained.Methods: The NIR-AF images were acquired using Heidelberg Retina Angiograph 2 (Heidelberg Engineering, Heidelberg, Germany), and sectional retinal images were obtained using Spectralis OCT (Heidelberg Engineering). The presence of a mosaic pattern and cystoid signs were determined qualitatively. (Read more...)
Outcomes of Changing Immunosuppressive Therapy after Treatment Failure in Patients with Noninfectious Uveitis – Corrected Proof
Purpose: To evaluate the outcomes of changing immunosuppressive therapy for noninfectious uveitis after failure.Design: Retrospective cohort study.Participants: Patients with noninfectious uveitis managed at 2 tertiary uveitis clinics in the United Kin…
Predictors of Matching in Ophthalmology Residency for International Medical Graduates – Corrected Proof
International medical graduates (IMGs) comprise approximately 25% of the United States’ (US) physician workforce and play a vital role in US healthcare by serving in medically underserved areas and by increasing diversity among physicians. However, it …
The 5-Year Incidence of Bleb-Related Infection and Its Risk Factors after Filtering Surgeries with Adjunctive Mitomycin C: Collaborative Bleb-Related Infection Incidence and Treatment Study 2 – Corrected Proof
Purpose: To report the 5-year incidence of bleb-related infection after mitomycin C–augmented glaucoma filtering surgery and to investigate the risk factors for infections.Design: Prospective, observational cohort study.Participants: A total of 1098 …
Herbert Herbert: His Corneal Pits and Scleral Slits – Corrected Proof
Purpose: To evaluate the life and professional work of the English ophthalmologist Herbert Herbert (1865–1942).Design: Historical study.Methods: The main sources for this investigation are Herbert’s approximately 65 published papers and 3 monographs….
Time to Clinically Significant Visual Acuity Gains after Ranibizumab Treatment for Retinal Vein Occlusion: BRAVO and CRUISE Trials – Corrected Proof
Purpose: To assess time to first achievement of clinically significant visual acuity (VA) gains from baseline in patients with retinal vein occlusion (RVO) receiving ranibizumab versus sham treatment.Design: Post hoc analyses of 2 phase 3 clinical tria…