Diagnostic Potential of Iris Cross-sectional Imaging in Albinism Using Optical Coherence Tomography – Corrected Proof

Purpose: To characterize in vivo anatomic abnormalities of the iris in albinism compared with healthy controls using anterior segment optical coherence tomography (AS-OCT) and to explore the diagnostic potential of this technique for albinism. We also investigated the relationship between iris abnormalities and other phenotypical features of albinism.Design: Prospective cross-sectional study.Participants: A total of 55 individuals with albinism and 45 healthy controls.Methods: We acquired 4.37×4.37-mm volumetric scans (743 A-scans, 50 B-scans) of the nasal and temporal iris in both eyes using AS-OCT (3-μm axial resolution). Iris layers were segmented and thicknesses were measured using ImageJ software. Iris transillumination grading was graded (Read more...)

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