Loss of Müller’s Cells and Photoreceptors in Macular Telangiectasia Type 2 – Corrected Proof
Purpose: To correlate postmortem histology from a patient with macular telangiectasia (MacTel) type 2 with previously recorded clinical imaging data.Design: Observational clinicopathologic case report.Methods: The distribution of retinal blood vessels was used to map the location of serial wax sections in color fundus and optical coherence tomography (OCT) images. Fluorescent immunohistochemistry was used to visualize markers for Müller's cells (vimentin and retinaldehyde-binding protein 1), photoreceptors (L-M opsin, rhodopsin, and cytochrome oxidase 2), and the outer limiting membrane (OLM) (zonula occludens 1 and occludin).Main Outcome Measures: Distribution of specific markers in immunohistochemistry on retinal sections through the fovea in relation to (Read more...)