Author reply

We thank Matonti et al for their interest in our study (SECURE). Matonti et al mention in their letter that the mean BCVA decrease of 4.3 letters from baseline observed in the SECURE study may be owing to retinal nerve fiber layer (RNFL) decrease and intraocular pressure (IOP) increase secondary to intravitreal injections of ranibizumab. The hypothetical link between RNFL and changes in BCVA cannot be substantiated based on the SECURE study, because RNFL was not assessed in the SECURE study or in its prestudies, EXCITE and SUSTAIN. Martinez de la Casa et al (Read more...)

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