Author reply

We would like to thank Hong et al for their comments regarding our recent publication. The intraocular safety evaluation after cyclosporine (CsA) drug delivery system (DDS) implantation was described in detail in the article. Complicated cataract was not specifically mentioned because it was not observed during the follow-up period. In our previous report, CsA DDS contained 1 mg of CsA, and the subsequent drug concentration in the aqueous humor was 10 ng/ml, with no complicated cataract. The safety of CsA DDS to the lens was associated with the extremely low CsA level, which did no harm to the biologic properties of the lens, as well as the appropriate site of DDS embedded in the inferior chamber angle, which gave CsA DDS no chance to move freely or contact with the lens surface, even if the patient head moved.