Change in Prostaglandin Expression Levels and Synthesizing Activities
We read with great interest the recently published study by Shim et al, which the authors described as a cross-sectional, case-control, clinical trial. As a single study, such a design is not possible because cross-sectional, case-control, and clinical trials are 3 distinct types of study designs. The authors conducted a cross-sectional analysis to investigate the associations of ocular irritation scores and concentrations of prostaglandin E2 to prostaglandin D2 in adult eyes with dry eye disease. In addition, in a separate analysis, eyes of the participants with dry eye disease were compared (Read more...)