Voriconazole for Fungal Keratitis

In their recently published trial, Sharma et al found topical voriconazole to be more effective than intrastromal voriconazole when added to topical natamycin in patients with recalcitrant fungal keratitis. This trial shares a similar protocol with several of our recent trials: a therapeutic exploratory trial (referenced by Sharma et al as “MUTT”), a therapeutic confirmatory trial (the first Mycotic Ulcer Treatment Trial or MUTT I), and a third trial for which results are not yet available (MUTT II). Here, we would like to clarify their reference to MUTT, and compare the results (Read more...)

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