Appearance of Regressing Drusen on Adaptive Optics in Age-Related Macular Degeneration – Corrected Proof
In age-related macular degeneration, material between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch's membrane are generally referred to as drusen. Although drusen “maturation” is characterized by accumulation of several layers of coiled membranous debris between the RPE and Bruch's membrane, in drusen regression there is evidence not only of reduced formation of membranous debris, but also of its removal by macrophage. Material not removed develops calcification.