We are pleased to receive comments regarding our manuscript reporting transsynaptic retrograde degeneration (TRD) of retinal ganglion cells after infarction in various areas of the brain. We measured retinal nerve fiber layer (RNFL) thickness to indirectly observe TRD of retinal ganglion cells. Previous work by Jindahra et al showed TRD of retinal ganglion cells after congenital or acquired occipital lobe injury. Our work differed from their study because our patients had acquired brain lesions owing to ischemic stroke. They had various stroke lesions, including lesions other than in the occipital lobe.