Genetic variants associated with lutein, zeaxanthin in AMD

Several genetic variants were associated with the role of lutein and zeaxanthin in reducing the risk of age-related macular degeneration, according to a large study.Data were culled from the Carotenoids in Age-Related Eye Disease Study (CAREDS). The study subset included 1,663 of 2,005 CAREDS participants who were genotyped for 424 single nucleotide polymorphisms (SNPs) from 24 candidate genes.Ninety-one percent of 337 AMD cases had early or intermediate AMD. Investigators used a logistic regression model to test SNPs for associations with AMD.

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