Double dose of anti-VEGF may reduce macular edema after irradiation for uveal melanoma

PHILADELPHIA — Double doses of intravitreal bevacizumab may reduce macular thickness and improve best corrected visual acuity in patients with post-radiation cystoid macular edema that does not respond to standard dosing, according to a study presented here. The 2.5 mg double dose may not be a treatment option for patients whose macular edema worsened following the standard dose of 1.25 mg, Arman Mashayekhi, MD, said at the Wills Eye Annual Conference. “[In] patients who got worse with the standard dose, none improved with the double dose either,” Mashayekhi said. “That may help us in selecting our patients. In fact, if we delete this group from the study, our success rates will improve from 33% to 41%.”