Fluorescence shows promise for detecting amyloid β in retinas of Alzheimer’s patients

ORLANDO, Fla. — Thioflavin S staining in the ex vivo retina, detected by polarimetry, showed an 84.2% sensitivity and 72.2% specificity in detecting Alzheimer’s disease, according to a poster presented here at the Association for Research in Vision and Ophthalmology meeting. Laura Emptage, a research assistant in the Campbell Labs at the University of Waterloo, and colleagues explained in their poster that because amyloid β is overexpressed in the brains of those with Alzheimer’s disease — and typically detected post-mortem — it is an accepted marker of the disease.

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