Alpha antagonists linked to increased risk of intraoperative floppy iris syndrome

The risk of intraoperative floppy iris syndrome, or IFIS, was markedly increased in patients who used selective or nonselective alpha-antagonists before cataract surgery, according to study findings.Data were culled from the Veterans Affairs Ophthalmic Surgical Outcomes Data Project conducted by the Veterans Health Administration. The retrospective study included 1,254 patients who used alpha antagonists before cataract surgery; 587 patients used selective alpha antagonists, 627 patients used nonselective alpha antagonists and 40 patients used both.

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