Corticosteroid use before <i>Acanthamoeba</i> keratitis diagnosis increases risk of poor visual outcome

Use of topical corticosteroid before the diagnosis of Acanthamoeba keratitis was highly predictive of worse visual outcomes, according to study findings.The retrospective cohort study included 196 eyes of 196 patients diagnosed with Acanthamoeba keratitis (AK) between January 1991 and April 2012. Patients were separated into two groups: the exposed cohort, which included patients treated with prior corticosteroids, and the unexposed cohort, which included patients treated without prior corticosteroids. The majority of patients were treated with a dual therapy of biguanide (polyhexanide 0.02, 0.06% or chlorhexidine 0.02, 0.2%) and diamidine (propamidine (Read more...)