New protocols for corneal cross-linking promisingly address limitations, complications

Today, so-called conventional corneal collagen cross-linking has become the gold standard to halt the course of progressive keratoconus. In this photoreticulation technique, the collagen fibers are bonded with the surrounding corneal matrix. Chemical toxicity leads to keratocyte and nerve fiber apoptosis and subsequently to a progressive renewal of the intracorneal cellular networks. Over time, both biochemical and biological mechanisms allow biomechanical stabilization of the anterior part of the cornea.

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