Corneal sealant has application in complex surgeries

Clear corneal wound architecture has been largely perfected for simple surgical procedures such as uncomplicated cataract removal. Typically, these incisions require minimal manipulation and result in wounds with few reported adverse effects and only the occasional need for sutures or other intervention. However, for more complex surgical procedures, wounds are not always self-sealing due to a combination of factors such as more wound manipulation and larger or multiple incisions.Compromised wound integrity is attributable to a number of factors, and even perfectly constructed wounds are subject to the effects of internal and external pressure or manipulation. While wound size plays a role in the ability of the incision to seal, the level of manipulation is the key indicator of how well a wound will heal. In addition, there are challenges and forces that could be encountered after surgery, including external manipulation, which may allow fluid into or out of the incision.