24-hour monitoring gives insights on circadian rhythm of IOP before and after SLT

Continuous 24-hour monitoring of IOP showed that the majority of patients with primary open-angle glaucoma have a nyctohemeral IOP rhythm with nocturnal acrophase. It also demonstrated that selective laser trabeculoplasty significantly lowers pressure but does not alter the nyctohemeral IOP rhythm.The prospective study was conducted in a sleep laboratory affiliated with the University Hospital of Grenoble, France, and included 14 patients with primary open-angle glaucoma. The Triggerfish contact lens sensor (Sensimed) was used for continuous 24-hour IOP monitoring before SLT and then at 1 month and 6 months after SLT treatment. All three monitoring sessions were preceded by a washout procedure to thoroughly eliminate any bias effect from medications. For 1 month before placing the lens, treatments were replaced with one drop twice a day of dorzolamide (Alcon), which was discontinued 1 week before lens placement.