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Longer duration of levofloxacin may lead to higher minimum inhibitory concentrations
Patients undergoing a longer duration of levofloxacin 1.5% administration after cataract surgery experienced higher minimum inhibitory concentrations of levofloxacin against Staphylococcus epidermidis, according to a study. Researchers randomized 103 patients who underwent cataract surgery to two groups: those who received 1 week of levofloxacin 1.5% ophthalmic solution and those who received 1 month duration of the drug. Each patient’s conjunctival sac was scraped for bacteria before administration of the solution, 1-week postoperatively, at the completion of administration, and again at 1, 3 and 6 months after administration completion.