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Corticosteroid-related adverse events increase with dose in noninfectious uveitis
A post hoc analysis of two clinical trials showed a significant dose-dependent correlation between corticosteroid treatment and adverse events in patients with noninfectious uveitis.The VISUAL-1 and VISUAL-2 studies investigated the safety and efficacy of Humira (adalimumab, AbbVie) as a potential maintenance therapy after corticosteroid tapering and discontinuation. The control group of these studies, in which a placebo was administered after discontinuation of corticosteroids, provided an ideal set of data to evaluate the incidence rate of dose-dependent corticosteroid-related adverse events, according to the study authors.