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Protein immunoreactivity associated with uveal melanoma metastasis
BAP1 immunohistochemical staining of primary uveal melanoma showed high capability to evaluate metastatic risk in a study. BRCA1-associated protein 1 (BAP1) is one of the five genes frequently mutated in uveal melanoma. Previous studies found a strong association between BAP1 inactivation and metastasis, suggesting that BAP1 may function as a metastasis suppressor.