Isotonic riboflavin with dextran used during cross-linking was found to significantly decrease corneal thickness, while dextran-free isotonic riboflavin significantly increased corneal thickness.
A retrospective study included two groups of patients with progressive keratoconus. Group A consisted of 100 cases that underwent saturation with isotonic riboflavin and dextran, and group B consisted of 100 cases that underwent saturation with isotonic riboflavin with hydroxypropyl methylcellulose.
Group A cases experienced a mean decrease of 51.4 µm in central corneal thickness (CCT). Group B
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