Intravitreal sustained delivery of human ciliary neurotrophic factor showed efficacy in slowing the progression of retinal degeneration in patients with macular telangiectasia type 2, a condition with no known effective therapy.
Ciliary neurotrophic factor (CNTF) is a neuroprotective agent that has reduced photoreceptor cell loss in animal models of retinal degeneration. It is produced by Neurotech Pharmaceuticals as an encapsulated cell-based drug delivery system with the name of Neurotech-501. Genetically modified human retinal pigment epithelium cells, encapsulated in a semipermeable hollow
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