The DRCR.net Protocol V clinical trial concludes that patients with center-involved diabetic macular edema and good vision can confidently be managed by observation, scheduling anti-VEGF injections only if vision deteriorates.
Protocol V addressed the unanswered question of whether anti-VEGF injections are the best strategy in the common clinical scenario of center-involved DME with good vision. Physicians often treat these eyes based on the good results obtained in clinical trials in which anti-VEGF treatment was evaluated in eyes with reduced visual acuity. Could patients with good vision be
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