Since its approval in 2016, corneal cross-linking has been gradually gaining popularity in the U.S. Reimbursement issues have been largely overcome, and the procedure is now covered by most insurance companies.
Currently, the FDA allows only the standard epi-off iLink procedure (Glaukos) with 30 minutes of riboflavin instillation (Photrexa Viscous, 0.146% riboflavin 5’-phosphate in 20% dextran ophthalmic solution) and 30 minutes of 3 mW/cm² UV irradiation, the traditional Dresden protocol. However, U.S. ophthalmologists are looking forward to bridging the gap with Europe, where CXL