Genetic inhibition of HMG-CoA reductase, a state that mimics long-term statin use, was associated with greater risk for developing cataract compared with individuals without genetic inhibition, researchers reported.
According to data published in the Journal of the American Heart Association, individuals with an especially rare variant of genetic HMG-CoA reductase inhibition experienced a fivefold risk for developing cataract and undergoing cataract surgery, compared with noncarriers of the variant.
“We were able to establish a link between genetic variants that mimic inhibition of HMGCR