Add-on low-dose prednisolone improves long-term disease activity and progression in senior patients with established rheumatoid arthritis, albeit with an increase in non-severe adverse events, according to data.
“Most experts agree that long-term [glucocorticoid (GC)] therapy is harmful, and existing guidelines suggest to avoid or use GC only as ‘bridging’ therapy; however, such opinions are based on observational studies with high potential for bias,” Maarten Boers, MD, PhD, of Amsterdam University Medical Centers and co-authors, wrote in Annals of the Rheumatic