Mitochondrial flavoprotein fluorescence may possibly serve as an indicator of age-related macular degeneration stage, helping to detect early disease and offering insights on how and when to treat patients, according to a study.
Oxidative stress-induced mitochondrial dysfunction is a well-known component of the pathophysiology of AMD. Flavoproteins serve an essential role in normal mitochondrial function. When oxidized, under blue light stimulation they emit a green autofluorescence signal that could potentially be used as a biomarker of mitochondrial dysfunction.
“Until recently,