Polygenic risk score is associated with an increased risk for primary open-angle glaucoma in patients with ocular hypertension, according to a speaker.
“Glaucoma is a highly heritable disease, and it is also very genetically complex, with 127 risk variants identified to date,” Rishabh Singh said at the American Glaucoma Society meeting. “While individually this risk variance may have a small effect, they still make a contribution to the aggregate genetic burden that a patient carries. We can measure that aggregate genetic burden in the form of a polygenic risk score.”