Stevens-Johnson syndrome and its more severe variant, toxic epidermal necrolysis, are rare and dangerous immunologic diseases.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) result in rapid-onset keratinocyte apoptosis and inflammation causing blistering and sloughing of the skin and the mucosal epithelium that lines the mouth, eyes and eyelids (Kohanim et al.).
SJS/TEN is usually induced by an adverse reaction to medication, most commonly antibiotics, antiepileptics and allopurinol. However, mycoplasma infections may also trigger a similar but clinically distinct condition