Tubulointerstitial Nephritis and Uveitis Syndrome in Children: A Prospective Multicenter Study – Corrected Proof
Purpose:
To evaluate the occurrence and characteristics of uveitis related to tubulointerstitial nephritis (TIN) in children.
Design:
Prospective, observational, multicenter, partly placebo-controlled treatment trial.
Participants:
Nineteen children with a biopsy-proven TIN.
Methods:
Patients were treated with prednisone or followed without treatment. In addition to the nephrologic evaluations, the prospective follow-up included structured ophthalmological examinations at the onset of TIN and at 3 and 6 months after the diagnosis.
Main Outcome Measures:
Occurrence, clinical features, and outcome of uveitis.
Results:
Some 84% (16/19) of the patients had uveitis, 83% (5/6) in the nontreatment group and 82% (9/11) in the prednisone-treated group. (Read more...)