Tubulointerstitial Nephritis and Uveitis Syndrome in Children: A Prospective Multicenter Study – Corrected Proof

Purpose: To evaluate the occurrence and characteristics of uveitis related to tubulointerstitial nephritis (TIN) in children. Design: Prospective, observational, multicenter, partly placebo-controlled treatment trial. Participants: Nineteen children with a biopsy-proven TIN. Methods: Patients were treated with prednisone or followed without treatment. In addition to the nephrologic evaluations, the prospective follow-up included structured ophthalmological examinations at the onset of TIN and at 3 and 6 months after the diagnosis. Main Outcome Measures: Occurrence, clinical features, and outcome of uveitis. Results: Some 84% (16/19) of the patients had uveitis, 83% (5/6) in the nontreatment group and 82% (9/11) in the prednisone-treated group. (Read more...)

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