More innovation needed to deliver anti-VEGF treatment to AMD patients

Patient compliance, or lack thereof, is a well-known issue that all ophthalmologists deal with every day. Studies, especially in the glaucoma literature, confirm that compliance decreases as the number of different drops required increases past one and the number of drops per drug increases past two.The best compliance is with one drop once a day, and even then many patients miss drops for days and/or do not take their drops properly — for example, neglecting to shake suspensions adequately to assure a good mix of drug into the vehicle, close their eyes for at least 30 seconds after administration to enhance absorption or wait at least 5 minutes between drops when using more than one.